Vectorlogics, Inc.

Birmingham, AL 35294
4 Employees

SBIR Award Summary

Total Number of Awards 15
Total Value of Awards $2.48MM
First Award Date 08/01/99
Most Recent Award Date 09/16/08

Key Personnel

Last Name Name Awards Contact
Korokhov Dr. Nikolay Korokhov 1 Message
Krasnykh Dr. Victor Krasnykh 5 Message
Mathis J Michael Mathis 2
Hedley Susan J Hedley 3
Kovesdi Imre Kovesdi 3
Mikheeva Galina V Mikheeva 1

15 Awards Won

Phase 2 STTR

Agency: Department of Health & Human Services
Topic: PA-07-81
Budget: 09/16/08 - 08/31/09

DESCRIPTION (provided by applicant): Studies of the molecular mechanisms underlying neoplastic transformation and progression have resulted in the understanding that cancer is a genetic disease, deriving from the accumulation of a series of acquired genetic lesions. Despite advances in chemotherapy, radiation delivery, and surgical treatment re...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 07/01/08 - 06/30/10

DESCRIPTION (provided by applicant): The recognition that most cancers possess tumor-specific antigens or over-express antigens present in normal tissue, which can be immunogenic, provides the rational for using immunotherapy approaches as treatments for cancer patients. One such approach is delivery of the tumor-associated antigen (TAA) to the ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 09/15/07 - 03/14/08

DESCRIPTION (provided by applicant): The emerging threat of bio-terrorism provides a major challenge to protect the civilian population through standard prophylactic vaccine means. The recent anthrax attacks highlighted the urgent need to develop vaccine strategies that act rapidly to the threat of the biological pathogen, and which can be produ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 05/30/07 - 10/30/07

DESCRIPTION (provided by applicant): Conditionally replicative adenovirus vectors (CRAds) are novel vectors with utility as virotherapy agents for alternative cancer therapies. These vectors already have established a broad safety record in humans. However, two confounding problems limit efficacy of these drug candidates, the paucity of the nati...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-06
Budget: 09/15/06 - 03/14/07

DESCRIPTION (provided by applicant): Adenovirus vectors are employed in a wide range of gene therapy and vaccine applications due to several attractive features such as high titer attainment, structural stability, broad infectivity, established protocols for genetic manipulation and high levels of transgene expression with lack of host genome in...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/06 - 07/31/07

DESCRIPTION (provided by applicant): A number of characteristics of the Adenovirus type 5 (Ad5) make it an optimal gene therapy/virotherapy vector suitable for a wide array of cancer therapeutic approaches. Despite these advantages, overall ifficacy remains limited by sub-optimal adenovirus delivery to cancer tissues. 1 conceptual approach to ov...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/14/06 - 05/31/07

DESCRIPTION (provided by applicant): Conditionally replicative adenoviruses (CRAds) represent an important novel approach for cancer therapy. CRAd agents are designed to specifically replicate in and kill tumor cells to yield an effective yet safe therapeutic outcome. Although their great potential has awarded them rapid translation into human c...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/06 - 10/31/06

DESCRIPTION (provided by applicant): Adenovirus vectors are employed in a wide range of gene therapy and vaccine applications due to several attractive features such as high titers, structural stability, broad infectivity, established protocols for genetic manipulation and high levels of transgene expression with lack of host genome integration....

Phase 2 SBIR

Agency: Office of the Secretary of Defense
Topic: OSD01-DHP01
Budget: 08/20/02 - 08/20/04

Anti-cancer immunization is limited by the poor immunogenicity of tumor-associated antigens (TAAs) normally used for vaccination. This problem may be overcome by direct adenovirus-mediated delivery of TAAs to dendritic cells (DCs), which play a central role in the generation of the immune response. The specificity and efficiency of this vaccinat...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/17/02 - 12/17/03

DESCRIPTION (provided by applicant): Conditionally replicative adenoviruses (CRAds) propagate selectively in tumors and have been used to achieve extensive lysis and transduction of tumors. It is important for these replicative viruses to achieve tumor-selective replication to reduce their toxicity. Our group has develop...

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