490 Biotech, Inc.

KNOXVILLE, TN 37996

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $2.93MM
Active Awards 2 valued at $1.02MM
First Award Date 02/18/13
Most Recent Award Date 09/30/17

2 Active Awards Valued at $1.02MM

Award Title Awarding Agency Phase Award amount Start Date End Date
Development of a high-throughput screen to detect the effects of both pre- and post-biotransformed ... HHS 2 $523K 09/30/17 08/31/18
Expressing humanized bacterial luciferase in stem cells: Moving beyond fireflyluciferase to expand ... HHS 2 $496K 09/01/17 08/31/18

Key Personnel

Last Name Name Awards Contact
Morrison Dan Morrison 10 Message
Ripp Steven Ripp 1 Message
SAYLER GARY S SAYLER 1

10 Awards Won

Phase 2 SBIR Active

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/30/17 - 08/31/18

Development of a high-throughput screen to detect the effects of both pre- and post- biotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate-free autobioluminescent signal generation can det...

Phase 2 STTR Active

Agency: Department of Health & Human Services
Topic: PA-16-303
Budget: 09/01/17 - 08/31/18

Expressing humanized bacterial luciferase in stem cells: Moving beyond firefly luciferase to expand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology Transfer (STTR) Phase II project proposes to develop complementary autonomously bioluminescent (autobioluminescent) in vitro stem...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 07/01/16 - 06/30/17

? DESCRIPTION (provided by applicant): Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summary This Small Business Innovation Research Phase II project proposes to build upon our successful Phase I demonstration of autonomous endocrine ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-ES-15-006
Budget: 09/01/15 - 08/31/16

DESCRIPTION (provided by applicant): Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCs Project Summary. This Small Business Innovation Research (SBIR) Phase I project proposes to develop autonomously bioluminescent induced pluripotent s...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-13-224
Budget: 08/01/15 - 07/31/16

DESCRIPTION (provided by applicant): This Small Business Technology Transfer (STTR) Phase I project proposes to develop autonomously bioluminescent human stem cells for continuous, reagent-free, and real-time bioimaging to address the National Institutes of Health's request for new techniques for non-invasive, long-term tracking of stem cell sur...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 07/15/15 - 06/30/16

DESCRIPTION (provided by applicant): Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summary This Small Business Innovation Research Phase II project proposes to build upon our successful Phase I demonstration of autonomous endocrine disr...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 07/01/15 - 12/31/15

DESCRIPTION (provided by applicant): Development of a high-throughput screen to detect the effects of both pre- and post- biotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase I project proposes to engineer a panel of autonomously bioluminescent human cell lines for ...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 8.5
Budget: 05/11/15 - 12/31/15

Dioxin and other dioxin-like chemicals are persistent environmental pollutants that threaten human and animal health due to their stability in the environment and their ability to accumulate in the food chain toward eventual human consumption. Incidents of dioxins being found in the food and animal feed chain have led to numerous recalls with co...

Phase 1 SBIR

Agency: National Science Foundation
Topic: BC-2013
Budget: 01/01/14 - 12/31/14

This Small Business Innovation Research (SBIR) Phase I project proposes to develop self-generated bioluminescence in zebrafish to create improved models for new drug discovery, therapeutic testing, and biomedical disease imaging. Zebrafish share many common anatomical, developmental, and physiological features with humans, including disease path...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 02/18/13 - 07/31/13

DESCRIPTION (provided by applicant): Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summary This Small Business Innovation Research Phase I project proposes to engineer an autobioluminescent human cell line for improved screening of chemi...

Load More