Brookings, SD 57006

SBIR Award Summary

Total Number of Awards 2
Total Value of Awards $190K
First Award Date 01/01/10
Most Recent Award Date 01/01/11

Key Personnel

Last Name Name Awards Contact
Zhao Mojun Zhao 2 Message
Francis David H. Francis 2 Message

2 Awards Won

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 8.3-2011
Budget: 01/01/11 - 12/31/11

Enterotoxigenic Escherictia coli causes diarrhea (E. coli scours) in young weaned pigs. There currently are no licensed killed vaccines for the disease, and the available living vaccines do not express toxins which should be a major target of a vaccine. This lack of toxin antigens may affect how well the vaccines protect pigs. We have recently d...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 8.3-2010
Budget: 01/01/10 - 12/31/10

We have established that E. coli heat labile enterotoxin (LT) is an excellent mucosal adjuvant (immune enhancer) for stimulating immunity in young pigs and does not cause diarrhea or other adverse reactions when administered by intranasal inoculation, even at a relatively high dosage. Co-administration of LT and the K88 fimbriae from porcine ent...