Abzyme Therapeutics, LLC

POTTSTOWN, PA 19464
http://www.abzymetx.com

SBIR Award Summary

Total Number of Awards 16
Total Value of Awards $4.18MM
First Award Date 06/15/11
Most Recent Award Date 09/25/17

Key Personnel

Last Name Name Awards Contact
Tran Hiep T Tran 15 Message
Vo Tram Vo 2 Message
SWOBODA ROLF K SWOBODA 2 Message

16 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/25/17 - 08/31/18

Abstract. Immunotherapy is one of the most promising approaches for treatment of various human diseases including cancers, autoimmune and infectious diseases. However, systemic immunotherapies have been ineffective for central nervous system (CNS) disorders because the blood-brain barrier (BBB) limits their delivery to the brain. Development of ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/15/17 - 08/31/18

ASBTRACT. Arginylation mediated by arginyltransferase (ATE1) is a posttranslational modification that plays a global role in mammals. Arginylation is essential for mammalian embryogenesis and regulation of the cytoskeleton function in cell migration, a process that plays key roles during tissue morphogenesis and cancer metastases. Arginylation o...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/01/17 - 08/31/18

? DESCRIPTION (provided by applicant): Monoclonal antibodies are used for treatment of a wide range of diseases from cancer to infectious diseases. However, development of antibodies with high affinity and specificity is still time- consuming, labor-intensive and unpredictable, especially to low immunogenic or toxic targets. A new approach fo...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/01/16 - 08/31/17

? DESCRIPTION (provided by applicant): Monoclonal antibodies are used for treatment of a wide range of diseases from cancer to infectious diseases. However, development of antibodies with high affinity and specificity is still time- consuming, labor-intensive and unpredictable, especially to low immunogenic or toxic targets. A new approach f...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-DA-16-005
Budget: 07/01/16 - 06/30/17

Project Summary: It is known that protein activity can be modulated by post-translational proteinphosphorylation. Phospho-specific antibodies have greatly advanced understanding of the mechanisms ofprotein activation and signaling in cellular pathways. Post-transcriptional RNA modification is morecomplicated as there are 66 known RNA modificatio...

Phase 1 SBIR

Agency: Department of Defense
Topic: CBD161-004
Budget: 06/14/16 - 12/13/16

Alphavirus infection, which may cause encephalitis and death, are recognized as potential biological warfare agents. There are no approved medical countermeasures against diseases caused by Alphaviruses. In this project, thermostable single domain antibodies capable of crossing the blood brain barrier (BBB) and neutralizing encephalitic viruses ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-019
Budget: 03/13/16 - 11/30/16

? DESCRIPTION (provided by applicant): Thanks to their exquisite specificity and sensitivity, monoclonal antibodies (Mab) are the most important research tool for detection, localization and quantification of cellular proteins and widely used for diagnosis and treatment of various human diseases. Conventional hybridoma approach for generating...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 07/01/15 - 06/30/16

DESCRIPTION (provided by applicant): Thanks to their exquisite specificity and sensitivity, monoclonal antibodies (Mab) have found a broad application in research, diagnosis and therapy. For treatment of human diseases, fully human antibodies are the most desirable as they are generally not immunogenic and well-tolerated. While there are several...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-13-327
Budget: 06/01/15 - 11/30/15

DESCRIPTION (provided by applicant): Thanks to their exquisite specificity and sensitivity, monoclonal antibodies (Mab) are the most important research tool for detection, localization and quantification of cellular proteins and widely used for diagnosis and treatment of various human diseases. Conventional hybridoma approach for generating mono...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 8.3
Budget: 04/23/15 - 12/31/15

The need for segregation of poultry based on sex is driven by gender-related differences in growth rate, market age, management practices, and nutritional requirements. Each day, global poultry industry staff would ideally like to determine the gender of > 150 million newly hatched birds. Currently, this can be done only manually at the hatch...

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