Trellis Bioscience, LLC

MENLO PARK, CA 94025

SBIR Award Summary

Total Number of Awards 21
Total Value of Awards $14.2MM
First Award Date 02/01/04
Most Recent Award Date 07/28/17

Key Personnel

Last Name Name Awards Contact
Harriman William D Harriman 2
Collarini Ellen J. Collarini 1
Usinger William Robert Usinger 4
Kauvar Lawrence Kauvar 14

21 Awards Won

Phase SBIR

Agency: Department of Health & Human Services
Topic: PAR-16-027
Budget: 07/28/17 - 06/30/18

Abstract The CDC estimates that 65-80% of clinically significant drug resistant bacterial infections are drug refractory due to a change in physiological state of pathogens associated with biofilm formation. TRL1068 is a high affinity (100 pM) native human monoclonal antibody (mAb) that disrupts biofilms by extracting a key bacterial scaffolding...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-123
Budget: 07/01/17 - 06/30/18

DESCRIPTION (provided by applicant): Trellis Bioscience's CellSpot technology for identification of rare human antibodies with high specificity and affinity against multiple antigen has enabled discovery of highly efficacious strain- independent antibodies to Respiratory Syncytial Virus and to Cytomegalovirus. We have now applied CellSpot to iso...

Phase SBIR

Agency: Department of Health & Human Services
Topic: PAR-16-027
Budget: 05/01/17 - 04/30/18

Abstract Human cytomegalovirus (HCMV) is the major viral cause of medical complications associated with bone marrow and organ transplantation. Viral transmission from mother to fetus is implicated in ~15% of stillbirths and ~16,000 birth defects annually in the US. Passive immunization using human immune globulin (HIG) has shown promising activi...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PAR-14-088
Budget: 02/01/17 - 01/31/18

? DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease, leading annually to 200,000 deaths and 3 million hospitalizations of young children worldwide. Immune prophylaxis with a monoclonal antibody (mAb), Synagis(tm) (Medimmune, Inc.), was shown to be effective 15 years a...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 07/01/16 - 06/30/17

Abstract About 65-80% of serious bacterial infections are biofilm-mediated. Not only do biofilms provide ananchor and physical protection from the immune system for bacterial cells, but the physiology and geneticprogramming of bacteria also shifts between the planktonic (free floating) and sessile (stationary) states.Most notably, antibiotic sen...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-123
Budget: 07/01/16 - 06/30/17

DESCRIPTION (provided by applicant): Trellis Bioscience's CellSpot technology for identification of rare human antibodies with high specificity and affinity against multiple antigen has enabled discovery of highly efficacious strain- independent antibodies to Respiratory Syncytial Virus and to Cytomegalovirus. We have now applied CellSpot to iso...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PAR-14-088
Budget: 02/01/16 - 01/31/17

? DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease, leading annually to 200,000 deaths and 3 million hospitalizations of young children worldwide. Immune prophylaxis with a monoclonal antibody (mAb), Synagis(tm) (Medimmune, Inc.), was shown to be effective 15 years a...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-123
Budget: 07/01/15 - 06/30/16

DESCRIPTION (provided by applicant): Trellis Bioscience's CellSpot technology for identification of rare human antibodies with high specificity and affinity against multiple antigen has enabled discovery of highly efficacious strain- independent antibodies to Respiratory Syncytial Virus and to Cytomegalovirus. We have now applied CellSpot to iso...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-14-072
Budget: 07/01/15 - 06/30/16

DESCRIPTION (provided by applicant): About 70-80% of serious bacterial infections are biofilm-mediated. Not only do biofilms provide an anchor and physical protection for bacterial cells, but the physiology and genetic programming of bacteria also shifts between the planktonic (free floating) and sessile (stationary) states. Most notably, antibi...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-123
Budget: 02/01/15 - 01/31/16

DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) is the major viral cause of birth defects and of medical complications associated with organ transplantation. Passive immunization using human immune globulin (HIG) has been shown to prevent disease. As pooled plasma, however, HIG is a variable product that potentially contains in...

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