Recombinetics, Inc.

Saint Paul, MN 55104

SBIR Award Summary

Total Number of Awards 13
Total Value of Awards $4.96MM
First Award Date 05/16/11
Most Recent Award Date 09/19/17

Key Personnel

Last Name Name Awards Contact
Fahrenkrug Scott Christopher Fahrenkrug 3
CARLSON DANIEL FRED CARLSON 6
HARRIS PETER C. HARRIS 2
GARRY DANIEL J. GARRY 1
TOLAR JAKUB TOLAR 1
GOLDENRING JAMES RICHARD GOLDENRING 1
MELKAMU TAMENE MELKAMU 3
HARDING CARY O. HARDING 1
WATSON ADRIENNE LEIGH WATSON 2
ST.HELEN GIDEON ST.HELEN 1

13 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/19/17 - 07/31/18

PROJECT SUMMARY Polycystic kidney diseases (PKD) are a group of inherited disorders characterized by progressive cyst development in the kidney resulting in bilateral renal enlargement and often end stage renal disease (ESRD). The most common form of PKD, autosomal dominant PKD occurs at a frequency of 1:400 to 1:1000. Currently, there is no tre...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-180
Budget: 09/15/17 - 09/14/18

PROJECT SUMMARY ?lpha-1 antitrypsin (AAT) deficiency (AATD) and Chronic Obstructive Pulmonary Disease (COPD) are lung diseases, both of which share phenotypic features, including airflow obstruction and airway mucociliary dysfunction, attributed primarily to emphysema, a condition that defines damage and enlargement of the air sacs of the lungs...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-180
Budget: 09/01/17 - 08/30/18

PROJECT SUMMARY Nonalcoholic fatty liver disease (NAFLD) is the accumulation of fat in liver cells that advance to the more severe form called nonalcoholic steatohepatitis (NASH) characterized by inflammation, scarring (cirrhosis), liver failure and hepatocellular carcinoma, warranting liver transplant. Despite the profound economic and health ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/30/16 - 09/29/17

PROJECT SUMMARY Neurofibromatosis type 2 (NF2) is a genetic disorder associated with the development of nervous system tumors including vestibular schwannomas, meningiomas, cranial nerve tumors, and spinal tumors due to germline loss of one copy of the NF2 gene. While the prevalence of NF2 syndrome is only 1:33,000, NF2 is commonly lost sporadic...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-091
Budget: 09/30/16 - 08/31/17

PROJECT SUMMARY Alzheimer?s disease (AD) affects 44 million people worldwide, costing $605 billion yearly. One in nine Americans over the age of 65 have AD, the 6th leading cause of death in the US. Annually, $226 billion is spent to care for the 5.3 million Americans with AD. AD is the only cause of death in the top 10 that cannot be prevented,...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-092
Budget: 06/01/16 - 05/31/17

? DESCRIPTION (provided by applicant): Phenylketonuria (PKU) is one of the most common inborn errors of metabolism. PKU, commonly detected in infants during newborn screening, is due to recessively-inherited phenylalanine hydroxylase (PAH) deficiency. Current treatment strategies rely on restriction of dietary phenylalanine (Phe) intake to pre...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 05/05/16 - 04/30/17

? DESCRIPTION (provided by applicant): Microvillus inclusion disease (MVID) is the most severe cause of Congenital Diarrheal Diseases in neonates. MVID results from mutations that lead to malabsorption and life-threatening, intractable, secretory diarrhea. To date, no curative therapy exists. MVID patients are largely dependent on parenteral n...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 08/01/15 - 07/31/16

DESCRIPTION (provided by applicant): Immunodeficient rodents has revolutionized the study of regenerative medicine and cancer, to date, no analogous large animals with T, B, and NK-cell deficiency are available. We've used our novel multiplex gene- editing platform to knockout each allele of two genes, 1) Recombination Activating Gene (RAG2) an...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-223
Budget: 04/01/15 - 09/30/15

DESCRIPTION (provided by applicant): Organ transplantation is routinely used to replace entire organs in patients with a variety of health issues, yet there are currently more than 100,000 patients waiting to receive transplants due to lack of donors, and this number is rising dramatically. Exogenic organ production has the potential to alleviat...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-092
Budget: 09/10/14 - 08/31/15

DESCRIPTION (provided by applicant): Polycystic kidney diseases (PKD) are a group of inherited disorders characterized by progressive cyst development in the kidney resulting in bilateral renal enlargement and often end stage renal disease (ESRD). The most common form of PKD, autosomal dominant PKD occurs at a frequency of 1:400 to 1:1000. Curre...

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