Lucerna, Inc.

Brooklyn, NY 11226

SBIR Award Summary

Total Number of Awards 13
Total Value of Awards $3.39MM
First Award Date 08/01/11
Most Recent Award Date 09/18/17

Key Personnel

Last Name Name Awards Contact
Paige Jeremy S Paige 1
Wu Karen Wu 11 Message
SOMALINGA BALAJEE SOMALINGA 2

13 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/18/17 - 09/17/18

SUMMARY: Circular RNA (circRNA) is a class of covalently closed RNA species that are found in high abundance across tissues and species. Due to its circular nature, circRNA is resistant to exonucleases. Putative functions of circRNAs include: 1.) miRNA sequestration, 2.) RNA-binding protein scaffolding, 3.) mRNA trapping, and 4.) protein transla...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 02/01/17 - 01/31/18
PI: Karen Wu

SUMMARY RNA polymerase III (Pol III) is increasingly recognized as an important drug target and a rapidly developing area of academic research. Pol III is responsible for generating RNAs that are critical for cell growth, such as tRNAs, certain rRNAs, and various noncoding RNAs involved in processes such as mRNA splicing. These RNAs are required...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 07/05/16 - 06/30/17

SUMMARY:Targeting pyruvate kinase remains a challenge in cancer drug discovery. Despite compelling evidencehighlighting the importance of the pyruvate kinase isoform M2 (PKM2) in cancer cell growth and proliferation,drug discovery efforts targeting the glycolytic activities of PKM2 have yet to yield a successful drug candidate forclinical use. D...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-134
Budget: 07/01/16 - 06/30/17
PI: Karen Wu

DESCRIPTION (provided by applicant): Over the past 10 years it has become increasingly apparent that there is exceptional complexity in the RNA population in cells. This diverse RNA pool includes microRNAs, Piwi-interacting RNAs, termini- associated RNAs and other noncoding RNAs. In many cases, alterations in these RNAs, or proteins that bind to...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-134
Budget: 07/01/15 - 06/30/16
PI: Karen Wu

DESCRIPTION (provided by applicant): Over the past 10 years it has become increasingly apparent that there is exceptional complexity in the RNA population in cells. This diverse RNA pool includes microRNAs, Piwi-interacting RNAs, termini- associated RNAs and other noncoding RNAs. In many cases, alterations in these RNAs, or proteins that bind to...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-335
Budget: 09/01/14 - 12/31/14
PI: Karen Wu

DESCRIPTION: Sirtuins and ADP ribosyltransferases (ARDTs) are two families of related enzymes that have important medically relevant functions. For example, SIRT3, a mitochondrial sirtuin, controls mitochondrial function, and thereby exerts a strong effect on metabolism, obesity, type 2 diabetes, and metabolic syndrome. There is a major need to...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-088
Budget: 07/01/14 - 06/30/15
PI: Karen Wu

PROJECT SUMMARY ! Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder that that predominately affects adults over the age of 50. Individuals afflicted with FXTAS develop tremor, ataxia, Parkinson-like symptoms, and slowly lose their cognitive abilities to the point that they are completely dependent on...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-134
Budget: 07/01/14 - 06/30/15
PI: Karen Wu

PROJECT SUMMARY Over the past 10 years it has become increasingly apparent that there is exceptional complexity in the RNA population in cells. This diverse RNA pool includes microRNAs, Piwi-interacting RNAs, termini- associated RNAs and other noncoding RNAs. In many cases, alterations in these RNAs, or proteins that bind to these RNAs, have bee...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-335
Budget: 09/18/13 - 08/31/14
PI: Karen Wu

DESCRIPTION: Sirtuins and ADP ribosyltransferases (ARDTs) are two families of related enzymes that have important medically relevant functions. For example, SIRT3, a mitochondrial sirtuin, controls mitochondrial function, and thereby exerts a strong effect on metabolism, obesity, type 2 diabetes, and metabolic syndrome. There is a major need to...

Phase 1 SBIR

Agency: National Science Foundation
Topic: BC-2012
Budget: 01/01/13 - 12/31/13
PI: Karen Wu

This Small Business Innovation Research (SBIR) Phase I project involves the development of fluorescent metabolite sensors that enable high-throughput screening of genetically improved biofuel-producing cells. Currently, there are no analytical technologies that can screen large cell populations to identify metabolically superior cells for the pu...

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