Avantgen, Inc.

San Diego, CA 92121
http://www.avantgen.com/

SBIR Award Summary

Total Number of Awards 12
Total Value of Awards $4.77MM
First Award Date 09/01/08
Most Recent Award Date 03/01/16

Key Personnel

Last Name Name Awards Contact
Billheimer Jeffrey Billheimer 1
Fan Xiaomin Fan 11
Devi Lakshmi A Devi 3
FAN XIAMON FAN 1

12 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 03/01/16 - 02/28/17

DESCRIPTION (provided by applicant): The development of addiction involves the dopaminergic reward pathway and downstream negative changes that lead to craving and repeat self-administration. While it is clear this process involves changes in neuronal plasticity t the synapse junction, the exact changes at the protein level leading to the develo...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/22/15 - 09/21/17

Despite the discovery of over 1400 potential cancer biomarkers, translation of the discovery into clinical application has been very slow due to the lack of well-validated quantitative methods for assaying protein levels. Methods combining immune-enrichment of peptides derived from low abundance proteins and stable isotope dilution with mass spe...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-DK-14-008
Budget: 09/01/15 - 08/31/16

DESCRIPTION (provided by applicant): With prediabetes and diabetes reaching epidemic proportions, there is an urgent need to identify more effective therapeutics. Diabetes is characterized by elevated levels of the peptide hormone glucagon,, and inappropriate suppression of glucagon during an oral glucose tolerance test. Glucagon plays a major r...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 03/01/15 - 02/29/16

DESCRIPTION (provided by applicant): The development of addiction involves the dopaminergic reward pathway and downstream negative changes that lead to craving and repeat self-administration. While it is clear this process involves changes in neuronal plasticity t the synapse junction, the exact changes at the protein level leading to the develo...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-DA-15-001
Budget: 09/15/14 - 08/31/15

DESCRIPTION (provided by applicant): RNA editing and post-transcriptional modification is emerging as a key epigenetic mechanism for fine tuning genetic diversity and RNA function of particular importance in the brain. However, while some RNA editing processes have been relatively well described, other RNA modifications are poorly understood and...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/01/14 - 08/31/15

DESCRIPTION (provided by applicant): Since substantial neuronal loss has already occurred by the time Alzheimer's Disease (AD) manifests clinically, considerable research has been directed towards developing biomarkers for the reliable diagnosis of mild AD and the prodromal stage of mild cognitive impairment. The best studied biomarkers, A1-42 p...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 05/01/13 - 04/30/14

DESCRIPTION (provided by applicant): The development of addiction involves the dopaminergic reward pathway and downstream negative changes that lead to craving and repeat self-administration. While it is clear this process involves changes in neuronal plasticity t the synapse junction, the exact changes at the protein level leading to the develo...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-081
Budget: 09/01/12 - 08/31/13

DESCRIPTION (provided by applicant): Despite the prevalence of serious mental illness, our current understanding of the pathophysiology of mental disorders is limited. In part, this is due to the complexity of the CNS and difficulty of recapitulating such illnesses in animal models. While G-protein coupled receptor families for various neurotran...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-081
Budget: 09/08/11 - 08/31/12

DESCRIPTION (provided by applicant): Despite the prevalence of serious mental illness, our current understanding of the pathophysiology of mental disorders is limited. In part, this is due to the complexity of the CNS and difficulty of recapitulating such illnesses in animal models. While G-protein coupled receptor families for various neurotran...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 08/01/10 - 01/31/12

DESCRIPTION (provided by applicant): There is mounting evidence indicating that endothelial lipase (EL) plays a key role in the regulation of circulating cholesterol levels by modulating high-density lipoprotein-cholesterol (HDL-C) levels and hence reverse cholesterol transport. Therefore, EL provides a promising target for therapeutic intervent...

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