Helix Therapeutics, LLC

New Haven, CT 06511

SBIR Award Summary

Total Number of Awards 2
Total Value of Awards $328K
First Award Date 05/01/08
Most Recent Award Date 08/01/10

Key Personnel

Last Name Name Awards Contact
Vovis Gerald Francis Vovis 2

2 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 08/01/10 - 07/31/11

DESCRIPTION (provided by applicant): This is a proposal to test the feasibility of using triplex-forming oligonucleotides to correct the sickle cell disease (SCD) mutation in human CD34+ cells. SCD is one of the most common human genetic diseases and is the result of one specific inherited mutation in the 2-globin gene. Hydroxyurea is currently ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 05/01/08 - 10/31/10

DESCRIPTION (provided by applicant): The proposed work is to develop a therapeutic gene targeting agent for the treatment of HIV disease. Our approach is to use triplex-forming oligonucleotides (TFOs) and peptide nucleic acids (PNAs), which bind to duplex DNA in a sequence-specific manner. Initial work has demonstrated that TFOs can stimulate re...