Klein Assoc., Inc.

DUBLIN, OH 43016
http://www.decisionmaking.com
55 Employees

SBIR Award Summary

Total Number of Awards 117
Total Value of Awards $26.6MM
First Award Date 01/01/83
Most Recent Award Date 08/15/17

117 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 08/15/17 - 07/31/18

Urinary tract infections (UTIs) are one of the most common types of bacterial infection encountered by humans throughout their lifespan and are a major health problem afflicting millions of people each year. Gram-negative bacteria cause the majority of infections of which Escherichia coli is the primary pathogen and prone to antibiotic resistanc...

Phase 1 SBIR

Agency: Department of Defense
Topic: CBD161-004
Budget: 06/14/16 - 12/13/16

Alphaviruses pose significant risks to warfighters where encephalitic virus infection can lead to death. There is no effective treatment for alphavirus induced encephalitis and countermeasures are of high importance. Single domain antibodies (sdAb) are low molecular weight engineered antibody fragments composed of a single heavy-chain variable d...

Phase 1 SBIR

Agency: Army
Topic: A15-054
Budget: 09/21/15 - 04/20/16

Bacteriophages (phages), viruses which specifically infect and lyse bacteria, are attractive alternatives to antibiotic therapy as they are naturally occurring, amplify in the host, are inexpensive to produce and display narrow host ranges. This latter aspect is of particular interest to therapy as, unlike broad-spectrum antibiotics which kill t...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/15 - 07/31/16

To develop an automated universal microdevice harboring a library of species-specific tagged phages that will allow multiplexed collection of Gram-negative pathogens.

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 8.2
Budget: 05/06/15 - 12/31/15

Collectively Phytophthora species are estimated to cost the agricultur industry tens of billions of dollars per year globally. Phytophthora capsici a fungus-like plant pathogen is a scurge of vegetable crops known to infect over 45 species including peppers, cucumbers, squash, cantaloupe, watermelon, zucchini, pumpkin, eggplant, tomatoes, snap b...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 12/01/14 - 11/30/15

DESCRIPTION (provided by applicant): The RNA interference(RNAi)-mediated gene silencing has become an important technology for manipulating cellular phenotypes, mapping genetic pathways and discovering therapeutic targets, and has therapeutic potential. A key challenge to realizing the broad potential of RNAi technology is the need for safe and ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-DA-15-001
Budget: 09/01/14 - 08/31/15

DESCRIPTION (provided by applicant): Biological RNAs undergo extensive post-transcriptional modifications. These modifications are important in promoting the accuracy and efficiency of gene expression in biological systems. To decipher the functions of RNA modifications, robust analytical tools and methods that enable scientists to monitor, man...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/01/14 - 02/28/15

DESCRIPTION (provided by applicant): Guild proposes to develop an antisense oligomer-based antifungal effective against the human pathogen Aspergillus fumigatus. With a 40%-60% mortality rate, invasive aspergillosis (IA) due to A. fumigatus now surpasses invasive candidiasis as the most frequent fungal cause of death, especially amongst immunoco...

Phase 1 SBIR

Agency: Army
Topic: A14-043
Budget: 01/01/14 - 12/31/14

Current methods of species-specific bacterial detection and identification are complex, time-consuming, and often require expensive specialized equipment and highly trained personnel. There is a growing need for developing fieldable devices to combat both naturally occurring, and deliberate outbreaks of biothreat agents. Building upon Guild BioS...

Phase 1 SBIR

Agency: Defense Health Program
Topic: DHP14-004
Budget: 01/01/14 - 12/31/14

Guild BioSciences proposes to develop a self-contained, low-cost, disposable, easy to use, colorimetric test strip that enables soldiers to measure/monitor salivary Adiponectin protein, a unique biomarker whose decreased circulating level is an indicator of weight-gain metabolic processes. The proposed test strip requires no special training to ...

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