Nuvox Pharma, LLC

Tucson, AZ 85719

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $4.19MM
First Award Date 09/01/08
Most Recent Award Date 12/01/17

Key Personnel

Last Name Name Awards Contact
Unger Evan Charles Unger 8
Unger E F Unger 1
Porter Thomas R Porter 2
BROWN JOHN MARTIN BROWN 1
SCHECK ADRIENNE C SCHECK 1
WILLMANN JUERGEN KARL WILLMANN 2
KUTTY SHELBY KUTTY 1
STEA BALDASSARRE STEA 1

10 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 12/01/17 - 05/31/18

PROJECT SUMMARY/ABSTRACT Clinical Challenge: In acute trauma, in the civilian setting, hemorrhage is the second most leading cause of death.1 In the military setting, 90% of potentially preventable deaths are caused by hemorrhage due to trauma.2,3 56% of civilian and 87% of military mortality caused by traumatic hemorrhage occurs pre-hospitaliza...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: RFA-CA-16-008
Budget: 09/12/17 - 08/31/18

Glioblastoma multiforme (GBM) is a malignant primary brain tumor affecting about 12,000 new cases per year in the U.S. Average survival is only about 14-15 months. Radiation (RT) is most commonly administered as 30 fractions of 2 Gray each over 6-weeks with concomitant temozolomide (TMZ). GBM tumors are hypoxic. The primary mechanism of RT is cr...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 04/01/17 - 03/31/18

Due to multiple factors, time to administration of lytic therapy or emergent percutaneous coronary intervention (PCI) in acute ST segment elevation myocardial infarction (STEMI) may be delayed, resulting in loss of additional myocardial tissue. These delays are virtually impossible to overcome in remote ...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-15-270
Budget: 09/19/16 - 08/31/17

ABSTRACT Breast cancer is the second leading cause of cancer-deaths in women in the United States and early detection can help improve survival. While mammography is the current first-line imaging technique for early breast cancer detection, its diagnostic accuracy is limited in women with dense breast tissue. Ultrasound is often performed as a ...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-15-270
Budget: 09/01/16 - 08/31/17

Project Summary Staphylococcus is the most common cause of community- and hospital- acquired infective endocarditis worldwide. Staphylococcal (S. aureus) endocarditis is a serious health problem in children and adults that carries high morbidity and mortality. The incidence of this disease is increasing ...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-14-072
Budget: 03/15/16 - 02/28/17

? DESCRIPTION (provided by applicant): Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of cancer and patient survival depends upon the stage of diagnosis. While overall survival at diagnosis is only about 4-6 months, 30-40% of patients with stage I disease survive 5 years. The best currently available diagnostic test which is routine...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/25/14 - 08/31/15

DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is a highly aggressive, malignant brain tumor widely known to be hypoxic and hypoxia is an important factor in the poor response of GBM to treatment. The most common therapy for GBM is surgical excision followed by fractionated RT + chemotherapy. Still, after treatment, GBM patie...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 05/24/10 - 11/23/10

DESCRIPTION (provided by applicant): Tissue probe measurements and imaging show that tumor hypoxia is common in many cancers including head and neck cancer, cervical cancer, prostate cancer and many other solid tumors. Tumors with low oxygen concentrations are resistant to radiation treatment. New imaging techniques can be used to diagnose tumor...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 12/07/09 - 06/30/10
PI: E F Unger

DESCRIPTION (provided by applicant): The long-term objective of this Phase II SBIR proposal is to develop targeted microbubbles in conjunction with ultrasound for the treatment of vascular thrombosis (Sonothrombolysis). Gas-filled microbubbles are currently used as vascular ultrasound diagnostic agents because of their exquisite ability to refle...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-06-21
Budget: 09/01/08 - 08/31/10

DESCRIPTION (provided by applicant): Ultrasound mediated destruction (UMD) of intravenously injected microbubbles has the potential to alter blood brain barrier (BBB) permeability at selective locations within the central nervous system. This selective alteration in BBB permeability could have significant therapeutic potential in targeting drug ...

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