Navigen, Inc.

Salt Lake City, UT 84108

SBIR Award Summary

Total Number of Awards 36
Total Value of Awards $18.7MM
First Award Date 06/01/08
Most Recent Award Date 09/19/17

Key Personnel

Last Name Name Awards Contact
Navankasattusas Sutip Navankasattusas 8
Mueller Alan L Mueller 12
Welch Brett D Welch 11
Ostanin Kirill Ostanin 4
WETTSTEIN DANIEL A WETTSTEIN 2
FRANCIS JAMES NICHOLAS FRANCIS 1

36 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/19/17 - 08/31/18

PROJECT SUMMARY The cell surface CD47 protein is a marker of ?self? and signals through its receptor, signal-regulatory protein ? (SIRP?) expressed by macrophages, to transmit an anti-phagocytic (?don't-eat-me?) signal. CD47 is expressed by virtually all cell types, is overexpressed by cancer cells as a mechanism to avoid immune surveillance an...

Phase SBIR

Agency: Department of Health & Human Services
Topic: PAR-16-027
Budget: 09/18/17 - 08/31/18

PROJECT SUMMARY While modern HIV combination therapy has transformed HIV into a manageable chronic infection for many patients, HIV/AIDS remains a formidable global epidemic. Despite the effectiveness of combining drugs from different classes, side effects and drug resistance remain serious concerns for these life-long therapies. Thus, there is...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 08/01/17 - 07/31/18

PROJECT SUMMARY Respiratory syncytial virus (RSV) is the major cause of severe lower respiratory tract infections in children and infants, affecting an estimated 64 million people and causing up to 250,000 deaths worldwide per year (WHO). In the US, ~60,000 young children and ~175,000 adults are hospitalized annually due to RSV infection. High-...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 07/01/17 - 06/30/18

PROJECT SUMMARY Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) result from a common pathogenic process: pulmonary injury or infection triggers an overwhelming inflammatory response (?cytokine storm?) that results in increased endothelial and epithelial permeability and efflux of inflammatory cells, protein, and water fro...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 03/01/17 - 02/28/18

? DESCRIPTION (provided by applicant): Ebola virus causes highly lethal hemorrhagic fever in humans and non-human primates. Since the first outbreak in 1976, there have been over 20 natural human outbreaks with an average mortality rate near 70%. There are no approved agents to prevent or treat Ebola infection. Due to ease of dissemination, h...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 08/01/16 - 07/31/17

PROJECT SUMMARY Respiratory syncytial virus (RSV) is the major cause of severe lower respiratory tract infections in childrenand infants, affecting an estimated 64 million people and causing up to 250,000 deaths worldwide per year(WHO). In the US, ~60,000 young children and ~175,000 adults are hospitalized annually due to RSVinfection. High-risk...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 05/01/16 - 04/30/17

? DESCRIPTION (provided by applicant): Shiga toxins 1 and 2 (Stx1/2) are the primary virulence factors of Shiga toxin-producing E. coli (STEC), which are major food-, and waterborne pathogens afflicting both developed and developing countries. An estimated 265,000 STEC infections occur annually in the US. In addition to severe and often bloody...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 03/01/16 - 02/28/17

? DESCRIPTION (provided by applicant): Ebola virus causes highly lethal hemorrhagic fever in humans and non-human primates. Since the first outbreak in 1976, there have been over 20 natural human outbreaks with an average mortality rate near 70%. There are no approved agents to prevent or treat Ebola infection. Due to ease of dissemination, h...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/01/15 - 08/31/16

DESCRIPTION (provided by applicant): In spite of remarkable progress in management of rheumatoid arthritis (RA), a devastating autoimmune disease that affects 2.5 million Americans causing chronic inflammation of joints and surrounding tissues, the gap of unmet needs in this therapeutic field remains wide open. First of all, almost 50% of the pa...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 07/01/15 - 06/30/16

DESCRIPTION (provided by applicant): The development of non-opioid analgesics for the control of postsurgical pain is widely acknowledged as an important goal. The side effects of opioids, most notably respiratory depression, but also including sedation, nausea, constipation, and sleep impairment make their use challenging and even potentially l...

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