Retrotherapy, LLC

Bethesda, MD 20814

SBIR Award Summary

Total Number of Awards 4
Total Value of Awards $1.35MM
First Award Date 07/01/10
Most Recent Award Date 09/30/15

Key Personnel

Last Name Name Awards Contact
Mitchell Lloyd G Mitchell 4

4 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 09/30/15 - 09/29/16

DESCRIPTION (provided by applicant): Recent studies by my laboratory and collaborators and by others have demonstrated that RNA trans-splicing can correct mutations in many different genes in a wide range of disease model systems, including Huntington's disease. Trans-splicing is one of a handful of techniques that can convert the expression of ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-088
Budget: 06/01/14 - 05/31/15

Project Summary/Abstract B-precursor acute lymphoblastic leukemia (BPL) is the most common form of cancer in children and adolescents. This project addresses an urgent and unmet need for the treatment of aggressive, treatment refractory BPL. Two recent studies have found a deletion of CD22 exon 12 (CD22E12) in primary leukemic cells in the vast ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 02/20/11 - 01/31/13

DESCRIPTION (provided by applicant): Development of tools to modify globin gene expression in stem cells The objective of this proposal is to develop a treatment for patients with sickle cell disease. The development of methods for treating common genetic diseases, such as sickle cell disease remains an elusive goal. Gene therapy is a technology...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 07/01/10 - 06/30/12

DESCRIPTION (provided by applicant): This proposal seeks to develop a specific and efficient means to reduce or eliminate the production of the progerin protein, the cause of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). A de novo point mutation in codon 608 of the lamin A/C gene is present in nearly all cases of HGPS...