Yecuris Corporation

Portland, OR 97239

SBIR Award Summary

Total Number of Awards 7
Total Value of Awards $1.92MM
First Award Date 04/15/10
Most Recent Award Date 09/30/14

Key Personnel

Last Name Name Awards Contact
Grompe Markus Grompe 4
Wilson Elizabeth Marie Wilson 2
Nyberg Scott L Nyberg 1

7 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/30/14 - 06/30/15

DESCRIPTION (provided by applicant): Yecuris" has developed an in vivo genetic selection system (the FRG" KO mouse) that permits extensive humanization of murine liver by transplantation with human hepatocytes. This model has many potential commercial applications in drug development and testing, both in the in vivo and in vitro markets, .The mo...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 09/15/12 - 07/14/13

DESCRIPTION (provided by applicant): Chimeric mice with highly humanized livers have multiple potential applications in research and preclinical drug development both in the academic and commercial settings [1]. The applications include studies of human infectious diseases (hepatitis B and B, malaria etc.), drug metabolism and pharmacokinetics, ...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic: PA-10-051
Budget: 09/07/12 - 03/31/13

DESCRIPTION (provided by applicant): The FDA requires the use of human hepatocytes for preclinical drug testing by pharmaceutical researchers, but unfortunately the supply of these cells is severely limited. Currently, cadaveric donors and surgical liver resection specimens are currently the only available source of human hepatocytes. These samp...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic: PA-10-051
Budget: 04/01/12 - 03/31/13

DESCRIPTION (provided by applicant): The FDA requires the use of human hepatocytes for preclinical drug testing by pharmaceutical researchers, but unfortunately the supply of these cells is severely limited. Currently, cadaveric donors and surgical liver resection specimens are currently the only available source of human hepatocytes. These samp...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-09-094
Budget: 09/20/11 - 08/31/13

DESCRIPTION (provided by applicant): Translational research in the field of liver disease has been limited by a shortage of large animal models, which in turn has limited development of new therapies for metabolic liver disorders, acute liver failure, chronic (cirrhotic) liver disease, an hepatocellular carcinoma. While new transgenic and knocko...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic: PA-10-051
Budget: 07/01/11 - 03/31/12

DESCRIPTION (provided by applicant): The FDA requires the use of human hepatocytes for preclinical drug testing by pharmaceutical researchers, but unfortunately the supply of these cells is severely limited. Currently, cadaveric donors and surgical liver resection specimens are currently the only available source of human hepatocytes. These samp...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-09-081
Budget: 04/15/10 - 04/14/11

DESCRIPTION (provided by applicant): The liver is the site of many metabolic processes, including metabolism of xenobiotics such as pharmaceutical compounds. Drug metabolism is highly species specific and can vary significantly between individuals of the same species. To date no reliable experimental system capable of predicting the human-specif...