Affinergy ,inc

Durham, NC 27709

SBIR Award Summary

Total Number of Awards 89
Total Value of Awards $44.9MM
First Award Date 04/01/05
Most Recent Award Date 09/16/17

Key Personnel

Last Name Name Awards Contact
Hamilton Paul T Hamilton 13
Lamb Bruce Lamb 18
Gron Hanne Gron 11
Nair Shrikumar Ambujakshan Nair 19
Darby Martyn Darby 22
Hodges Jonathan A Hodges 5
Orgambide Guy Orgambide 1

89 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/16/17 - 08/31/18

SUMMARY/ABSTRACT Hepcidin is the peptide hormone responsible for regulating circulating iron concentrations. Overexpression of hepcidin results in severe iron deficiency and anemia, whereas hepcidin deficiency leads to iron overload. Not surprisingly, abnormalities in hepcidin production and circulating concentrations are highly correlated with ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 09/11/17 - 08/31/18

Preeclampsia is a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia is the largest cause of fetal and maternal morbidity and mortality, and accounts for nearly 16% of maternal deaths in the United States alone each year. Currently...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-287
Budget: 09/01/17 - 07/31/18

SUMMARY/ABSTRACT Preeclampsia is a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia is the largest cause of fetal and maternal morbidity and mortality, and accounts for nearly 16% annually of maternal deaths in the United States ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/01/17 - 08/31/18

? DESCRIPTION (provided by applicant): Severe Gram-positive infections are difficult to treat and associated with high mortality in hospital settings. Daptomycin is a broad spectrum antibiotic that has been successfully used to treat persisting Gram-positive infections, including skin and soft tissue infections, right-sided endocarditis, and ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-EB-16-001
Budget: 08/07/17 - 07/31/18

SUMMARY/ABSTRACT Preeclampsia is a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia is the largest cause of fetal and maternal morbidity and mortality, and accounts for nearly 16% annually of maternal deaths in the United States ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 08/03/17 - 07/31/18

SUMMARY/ABSTRACT Through modern surgical advancements, total hip replacements (THR) have become one of the most successful implant procedures to date. Even though long-term success rates are high, the staggering number of THR procedures performed (~365,000 per year in the United States alone) results in thousands of failed implants each year. M...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 06/01/17 - 05/31/18

? DESCRIPTION (provided by applicant): Fine-needle aspiration (FNA) cytology is the standard technique for evaluating thyroid nodules. Hemorrhaging is common during the procedure, however, leading to an aspirate that is significantly diluted by blood. Subsequent slide preparations are often suboptimal, resulting in nondiagnostic outcomes that...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 03/09/17 - 02/28/18

SUMMARY/ABSTRACT Dendritic cell (DC) therapy represents a new and promising immunotherapeutic approach for treatment of advanced stage cancers, with DC vaccines already approved for use in advanced prostate cancer, and more than 30 DC-based vaccines in the clinical development pipeline for other cancers. In particular, the US market for cancer v...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/22/16 - 08/31/17

SUMMARY/ABSTRACT Preeclampsia is a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia is the largest cause of fetal and maternal morbidity and mortality, and accounts for nearly 16% of maternal deaths in the United States alone eac...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/16/16 - 09/15/17

SUMMARY/ABSTRACT Lung cancer is the leading cause of cancer-related mortality in both men and women in United States with a dismal 5-year survival rate of 15%. While surgery is the only curative option, 70% of the patients are diagnosed with inoperable advanced disease, thus highlighting a lack of effective early screening methods. Typically, lo...

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