Panthera Biopharma, LLC

Aiea, HI 96701

SBIR Award Summary

Total Number of Awards 15
Total Value of Awards $6.95MM
First Award Date 08/08/06
Most Recent Award Date 06/01/09

Key Personnel

Last Name Name Awards Contact
Millis Sherri Zimmerman Millis 3
O'Malley Sean None O'Malley 2
Johnson Alan Thomas Johnson 8
Lehrer Axel T Lehrer 2

15 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-006
Budget: 06/01/09 - 05/31/11

DESCRIPTION (provided by applicant): Anthrax Lethal Factor (LF) is a metalloproteinase introduced into the cells of mammalian hosts during infection by the bacterium Bacillus anthracis. LF disrupts intracellular signaling pathways mediated by the MAPKKs, resulting in cell toxicity, sepsis, respiratory failure and rapid death. While antibiotic th...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-134
Budget: 06/01/09 - 11/30/10

DESCRIPTION (provided by applicant): Over half of the world population is at risk for infection by dengue virus, a mosquito borne member of the Flavivirus family that consists of four distinct serotypes. Approximately 50 to 100 million infections occur annually resulting in an estimated 500,000 cases of life threatening dengue hemorrhagic fever ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-006
Budget: 03/15/09 - 05/31/09

DESCRIPTION (provided by applicant): Anthrax Lethal Factor (LF) is a metalloproteinase introduced into the cells of mammalian hosts during infection by the bacterium Bacillus anthracis. LF disrupts intracellular signaling pathways mediated by the MAPKKs, resulting in cell toxicity, sepsis, respiratory failure and rapid death. While antibiotic th...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-34
Budget: 06/11/08 - 05/31/09

DESCRIPTION (provided by applicant): Over half of the world population is at risk for infection by dengue virus, a mosquito borne member of the Flavivirus family that consists of four distinct serotypes. Approximately 50 to 100 million infections occur annually resulting in an estimated 500,000 cases of life threatening dengue hemorrhagic fever ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-06
Budget: 06/01/08 - 05/31/09

DESCRIPTION (provided by applicant): Anthrax Lethal Factor (LF) is a metalloproteinase introduced into the cells of mammalian hosts during infection by the bacterium Bacillus anthracis. LF disrupts intracellular signaling pathways mediated by the MAPKKs, resulting in cell toxicity, sepsis, respiratory failure and rapid death. While antibiotic th...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 06/01/08 - 11/30/09

DESCRIPTION (provided by applicant): Ebola and Marburg viruses, the only members of the family Filoviridae, cause hemorrhagic fevers which are lethal in up to 90% of human cases. No vaccine or antiviral therapy currently exists to prevent or treat Filovirus infection. Due to their exceptional lethality and potential for weaponization, these viru...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 06/15/07 - 05/31/08

DESCRIPTION (provided by applicant): Ebola and Marburg viruses, the only members of the family Filoviridae, cause hemorrhagic fevers which are lethal in up to 90% of human cases. No vaccine or antiviral therapy currently exists to prevent or treat Filovirus infection. Due to their exceptional lethality and potential for weaponization, these viru...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-06
Budget: 06/15/07 - 05/31/08

DESCRIPTION (provided by applicant): Anthrax Lethal Factor (LF) is a metalloproteinase introduced into the cells of mammalian hosts during infection by the bacterium Bacillus anthracis. LF disrupts intracellular signaling pathways mediated by the MAPKKs, resulting in cell toxicity, sepsis, respiratory failure and rapid death. While antibiotic th...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAS-02-149
Budget: 04/01/07 - 03/31/08

DESCRIPTION (provided by applicant): Medicinal and computational chemistry methods will be used to optimize validated hit compounds found to inhibit botulinum neurotoxin. These inhibitors, discovered through in silico docking and confirmed with an in vitro fluorescence resonance energy transfer assay, show excellent properties of 'leadlikeness' ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAS-02-149
Budget: 04/01/07 - 03/31/09

DESCRIPTION (provided by applicant): The strain of West Nile virus now endemic in the continental United States is more virulent than the virus originally isolated in Africa and is classified as a category B priority pathogen by the NIAID. In only six years, it has spread throughout the continental United States, resulting in high morbidity and ...

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