Applied Molecular Evolution, Inc.

San Diego, CA 92121

SBIR Award Summary

Total Number of Awards 4
Total Value of Awards $1.03MM
First Award Date 07/15/99
Most Recent Award Date 09/01/02

Key Personnel

Last Name Name Awards Contact
Watkins Jeffry D Watkins 4

4 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/02 - 08/31/03

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/01 - 08/31/02

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/99 - 03/31/00

An antibody will be used as a protein scaffold for presenting peptide antagonists of the IL-1 receptor. Display of the peptides within the third complementarity-determining region (CDR) of the heavy chain will be optimized by synthesis of expression libraries in which the CDR positions of the peptides and the flanking CDR residues are randomize...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/15/99 - 01/14/00

Directed evolution techniques for engineering proteins in vitro combine random mutagenesis with screening assays that permit rapid selection of cells expressing protein variants with the desired characteristics. Directed evolution technology is not limited by the availability of structural information and is broadly applicable, as demonstrated b...