Originus, Inc.

Ann Arbor, MI 48108

SBIR Award Summary

Total Number of Awards 14
Total Value of Awards $3.86MM
First Award Date 05/01/04
Most Recent Award Date 08/01/13

Key Personnel

Last Name Name Awards Contact
Norton Camille S Norton 1
Morano Maria Ines Morano 13

14 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-096
Budget: 08/01/13 - 07/31/14

DESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated in at least an in vitro system. Enzymatic activity in freshly isolated hepatocytes is the "Gol...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-096
Budget: 08/15/12 - 07/31/13

DESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated in at least an in vitro system. Enzymatic activity in freshly isolated hepatocytes is the "Gol...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 01/25/11 - 08/14/12

DESCRIPTION (provided by applicant): Metabolism of administered drugs is determined by expression and activity of drug-metabolizing enzymes, such as cytochrome (CYP) P450 enzymes. These P450s are subject to inhibition and sometimes induction by xenobiotics, leading to possible pharmacokinetic drug-drug interactions between co-administrated drugs...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-071
Budget: 06/01/10 - 05/31/12

DESCRIPTION (provided by applicant): A current major challenge in pharmaceutical industry is to develop treatments for brain diseases and mental disorders such as depression, anxiety, schizophrenia, epilepsy, addiction and many more. Over the last decade, the drug discovery process has evolved dramatically following the continued advancement of ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-071
Budget: 06/03/09 - 05/31/10

DESCRIPTION (provided by applicant): A current major challenge in pharmaceutical industry is to develop treatments for brain diseases and mental disorders such as depression, anxiety, schizophrenia, epilepsy, addiction and many more. Over the last decade, the drug discovery process has evolved dramatically following the continued advancement of ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-375
Budget: 04/01/09 - 03/31/11

DESCRIPTION (provided by applicant): Recent advances in genomics and proteomics have produced rapid changes in drug discovery, increasing the speed of the High Throughput Screening (HTS) methods by using simple assays on isolated protein targets but sacrificing depth of information and making decisions difficult as to which compounds to pursue i...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-375
Budget: 04/01/09 - 03/31/11

DESCRIPTION (provided by applicant): Recent advances in genomics and proteomics have produced rapid changes in drug discovery, increasing the speed of the High Throughput Screening (HTS) methods by using simple assays on isolated protein targets but sacrificing depth of information and making decisions difficult as to which compounds to pursue i...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-75
Budget: 04/23/08 - 03/31/09

DESCRIPTION (provided by applicant): Recent advances in genomics and proteomics have produced rapid changes in drug discovery, increasing the speed of the High Throughput Screening (HTS) methods by using simple assays on isolated protein targets but sacrificing depth of information and making decisions difficult as to which compounds to pursue i...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-04-86
Budget: 09/01/07 - 08/31/09

DESCRIPTION (provided by applicant): The development of drugs aimed at reducing obesity and controlling eating disorders represents a major target of the pharmaceutical industry and has become one of the most exciting areas in drug discovery. The long term goal of this project is to develop tools for high throughput testing of drug compounds fr...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-04-086
Budget: 06/01/07 - 08/31/09

DESCRIPTION (provided by applicant): The development of drugs aimed at reducing obesity and controlling eating disorders represents a major target of the pharmaceutical industry and has become one of the most exciting areas in drug discovery. The long term goal of this project is to develop tools for high throughput testing of drug compounds fr...

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