Origene Technologies, Inc.

ROCKVILLE, MD 20850

SBIR Award Summary

Total Number of Awards 16
Total Value of Awards $5.79MM
First Award Date 04/01/99
Most Recent Award Date 09/22/15

Key Personnel

Last Name Name Awards Contact
Sun Zairen Sun 3
Jay Gilbert Jay 9
He Wei-Wu He 1
Cao Liang Cao 1
Ma Donghui Ma 2

16 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/22/15 - 09/21/17

This project will generate well-characterized high-affinity renewable rabbit monoclonal antibodies for use in targeted proteomic studies for the cancer, as well as other, research communities. These antibodies will enable large increases in sensitivity of protein detection assays by more than 1000-fold. We will generate high-affinity recombina...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 06/01/10 - 05/31/11

DESCRIPTION (provided by applicant): With its high sample density and multiplexed experimental settings, protein microarray technology is a powerful tool to study system biology at the whole proteome level. Protein microarray technology has a broad-range of utilities in biomedical research and pharmaceutical development. The most prominent appli...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/10/06 - 05/31/08

DESCRIPTION (provided by applicant): Full length cDNA clones are the most powerful tools for the functional analyses of genes. It remains difficult, however, to isolate a physical cDNA clone from complex cDNA libraries, especially for long or rare transcripts. Large-scale cDNA and genomic sequencing has resulted in thousands of reference sequenc...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/05 - 01/31/06

DESCRIPTION (provided by applicant): siRNA has emerged as a powerful genomics tool for functional analysis of human genes and potential drug discovery. This technology holds great promise for genome-wide functional genetic screens in mammalian cells. However, such screens have been hampered by a lack of effective siRNA product to achieve a highl...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/13/05 - 04/30/06
PI: Liang Cao

DESCRIPTION (provided by applicant): Protein kinases are key regulators of all aspects of neoplasia, including proliferation, angiogenesis, invasion, and metastasis. The completion of human genome allowed a more comprehensive examination of the entire kinase gene family that was last suggested to have 518 genes. These proteins mediate most of th...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/17/04 - 03/16/05

DESCRIPTION (provided by applicant): The latest build of human genome "build 34" contains 21,335 unique reference sequences that represent 17,869 unique loci. A survey of the open reading frame (ORF) size reveals that 635 reference sequences contain ORFs greater than 5 kb, but only 11 of those larger clones are commercially available through the...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/01 - 03/31/02

The development of a comprehensive gene expression database is essential for the discovery of functions for the estimated 100,000 human genes. The EST (expressed sequence tag) approach to identify gene sequences has already led to the assembly of approximately 50,000 unigenes, transcriptional units defined by overlapping EST sequences. While DN...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/01 - 08/31/01

DESCRIPTION: (Adapted from the investigator's abstract) This Fast-Track Phase I-Phase II STTR application is targeted at exploiting a novel and relevant experimental system for the study of angiogenesis (the growth of blood vessels) that has been developed at the partnering research institution. The authors will us...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/10/01 - 12/31/01

DESCRIPTION: (Adapted from the investigator's abstract) The EST (expressed sequence tag) paradigm to randomly sequence short stretches of expressed regions of genes as a means to identify full-length cDNAs, has been challenged by the lack of technological innovations to pick up where this technology left off. Th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/00 - 03/31/01

The development of a comprehensive gene expression database is essential for the discovery of functions for the estimated 100,000 human genes. The EST (expressed sequence tag) approach to identify gene sequences has already led to the assembly of approximately 50,000 unigenes, transcriptional units defined by overlapping EST sequences. While DN...

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