Blue Heron Biotechnology, Inc.

Bothell, WA 98021

SBIR Award Summary

Total Number of Awards 9
Total Value of Awards $3.89MM
First Award Date 08/01/00
Most Recent Award Date 05/01/07

Key Personnel

Last Name Name Awards Contact
Mulligan John Thomas Mulligan 9

9 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/07 - 04/30/08

DESCRIPTION (provided by applicant): Our goal in this project is to develop a uniform method for assembling large DNA molecules by ligation of sticky-ended fragments, regardless of the sequence, the fragment length, or the presence of restriction enzyme sites. If we are successful, this technology could be used to assemble full-length cDNAs, mam...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/06 - 04/30/07

DESCRIPTION (provided by applicant): Our goal in this project is to develop a uniform method for assembling large DNA molecules by ligation of sticky-ended fragments, regardless of the sequence, the fragment length, or the presence of restriction enzyme sites. If we are successful, this technology could be used to assemble full-length cDNAs, mam...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/05 - 02/28/07

DESCRIPTION (provided by applicant): In this application we propose to develop a simple and economical method for producing protein-display beads using a novel approach to controlling diffusion. Each bead will carry a different DNA sequence and the protein encoded by that sequence, and the method will produce beads carrying hundreds of millions...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/05 - 07/31/07

DESCRIPTION (provided by applicant): A small but significant fraction of recombinant clones are unstable in E. coli and thus difficult to clone and manipulate using the standard techniques of molecular biology. Many of these cDNAs and genes encode proteins that are toxic to the bacteria even when expressed at very low levels. For instance, onl...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/05/04 - 04/30/06

DESCRIPTION (provided by applicant): Our goal in this project is to develop a uniform method for assembling large DNA molecules by ligation of sticky-ended fragments, regardless of the sequence, the fragnent length, or the presence of restriction enzyme sites. If we are successful, this techndogy could be used to assemble full-length cDNAs, mamm...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/04 - 01/31/06

DESCRIPTION (provided by applicant): The long-term objective of this research is to provide researchers with fast, inexpensive access to any DNA sequence. Gene-based research is at the heart of drug discovery today. The ability to acquire and modify genes is integral to much of the basic research supported by the NIH; research which will be the ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/03 - 03/29/05

DESCRIPTION (provided by applicant): The acquisition and manipulation of genes is at the heart of biological research. Fast, accurate gene synthesis can reduce the cost and accelerate the speed cf research by allowing scientists to focus on experiments rather than spending time "cutting and pasting'' DNA. In addition, it has the potential to ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/05/03 - 01/31/04

DESCRIPTION (provided by applicant): The long-term objective of this research is to provide researchers with fast, inexpensive access to any DNA sequence. Gene-based research is at the heart of drug discovery today. The ability to acquire and modify genes is integral to much of the basic research supported by the NIH; research which will be the ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/00 - 03/31/02

Current methods for the synthetic manufacture of large fragments of DNA, a process commonly referred to as "gene synthesis," are expensive, labor- intensive and slow. We propose to develop a novel automated, solid-phase system for gene synthesis that will reduce costs and speed delivery times. Solid-phase synthesis has already been shown to work...