Bellbrook Labs, LLC

Madison, WI 53711

SBIR Award Summary

Total Number of Awards 38
Total Value of Awards $13.5MM
First Award Date 09/01/02
Most Recent Award Date 05/01/17

Key Personnel

Last Name Name Awards Contact
Lowery Robert G Lowery 28
Hayes Steven A Hayes 5
Meyvantsson Ivar Meyvantsson 3
Yin John Yin 2
BEEBE DAVID J BEEBE 1
HEEMSTRA JENNIFER MARGARET HEEMSTRA 1

38 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 05/01/17 - 04/30/18

? DESCRIPTION (provided by applicant): Epigenetic regulation of gene expression via methylation has been implicated in diverse diseases including cancer, diabetes and inflammation, and high throughput screening for histone methyltransferase (HMT) inhibitors is an area of intense drug discovery effort. However, there are significant shortcomin...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 05/01/17 - 10/30/18

SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon (IFN) response via activation of the STING (stimulator of interferon genes) receptor. The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP-AMP synthase, which produces a unique cyclic dinucleotide ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/20/16 - 08/31/17

Project Summary The broad goal of this project is the pharmacological validation of GIV, a nonreceptor guanine nucleotide exchange factor (GEF), for liver fibrosis. GIV sits at the hub of profibrogenic signaling in liver fibrosis, and is required for the key physiological events that lead to this condition: the migration, proliferation and extra...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-15-270
Budget: 09/13/16 - 09/12/17

Project Summary/Abstract High-throughput screening (HTS) is a powerful method for the discovery of new drug leads for target enzymes. In HTS assays, the activity of the target enzyme is often evaluated by quantifying a small-molecule or cofactor that is produced or consumed by the enzyme. While antibodies are a mainstay of small-molecule detecti...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 05/01/16 - 04/30/17

? DESCRIPTION (provided by applicant): Epigenetic regulation of gene expression via methylation has been implicated in diverse diseases including cancer, diabetes and inflammation, and high throughput screening for histone methyltransferase (HMT) inhibitors is an area of intense drug discovery effort. However, there are significant shortcoming...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-14-072
Budget: 06/01/15 - 05/31/16

DESCRIPTION (provided by applicant): Neurodegenerative diseases that affect motor neurons such as PD, ALS and HD represent an enormous unmet medical need that is growing with the aging population. Existing treatments have little or no effect on the course of disease, and patients have to cope with the loss of brain and body function for the rest...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 04/01/15 - 03/31/16

DESCRIPTION (provided by applicant): Inflammation has both beneficial and harmful effects in chronic neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), and paracrine signaling is central to the inflammatory response. Rapid advances in in vitro models that incorporate different neural cell types in the conte...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-088
Budget: 07/15/14 - 07/14/15

DESCRIPTION (provided by applicant): Epigenetic regulation of gene expression via methylation has been implicated in diverse diseases including cancer, diabetes and inflammation, and high throughput screening for histone methyltransferase (HMT) inhibitors is an area of intense drug discovery effort. However, there are significant shortcomings wi...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-096
Budget: 08/01/13 - 07/31/14

DESCRIPTION (provided by applicant): Approaches to drug screening typically involve dramatic compromises in order to achieve high throughput and hold down costs. Examples include the use of immortalized, heterologous cell lines, and genetic engineering to over-express the target protein and/or incorporate a fluorescent surrogate reporter to disp...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-096
Budget: 08/01/12 - 07/30/13

DESCRIPTION (provided by applicant): Approaches to drug screening typically involve dramatic compromises in order to achieve high throughput and hold down costs. Examples include the use of immortalized, heterologous cell lines, and genetic engineering to over-express the target protein and/or incorporate a fluorescent surrogate reporter to disp...

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