Discovery Genomics, Inc.

MINNEAPOLIS, MN 55413

SBIR Award Summary

Total Number of Awards 17
Total Value of Awards $6.08MM
First Award Date 02/01/03
Most Recent Award Date 04/15/15

Key Personnel

Last Name Name Awards Contact
Essner Jeffrey J Essner 1
Hackett Perry B Hackett 5
Ohlfest John R Ohlfest 2
Mcivor R Scott Mcivor 7
Hyland Kendra A. Hyland 2
HERBIG ERIC HERBIG 1

17 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 04/15/15 - 04/14/16

DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of - L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias, cardiopulmonary obstruction, progressive neurologic impairm...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 04/12/13 - 03/31/14

DESCRIPTION (provided by applicant): Pancreatic cancer represents the 10th most common cancer diagnosis, yet the 4th most common estimated cause of death. The only potential curative therapy for pancreatic cancer is surgical resection;however, few patients have tumors which can be respected. Pancreatic ductal adenocarcinoma, which represents 90%...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 02/01/13 - 01/31/14

DESCRIPTION (provided by applicant): Sleeping Beauty (SB) is a transposon system that has been extensively shown to be capable of mediating integration of new gene sequences into the chromosomes of target cells and tissues. At Discovery Genomics, Inc. (DGI), we are working to develop the SB transposon system for human gene therapy, with hemophil...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 02/01/12 - 01/31/13

DESCRIPTION (provided by applicant): Sleeping Beauty (SB) is a transposon system that has been extensively shown to be capable of mediating integration of new gene sequences into the chromosomes of target cells and tissues. At Discovery Genomics, Inc. (DGI), we are working to develop the SB transposon system for human gene therapy, with hemophil...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 02/09/11 - 01/31/12

DESCRIPTION (provided by applicant): Sleeping Beauty (SB) is a transposon system that has been extensively shown to be capable of mediating integration of new gene sequences into the chromosomes of target cells and tissues. At Discovery Genomics, Inc. (DGI), we are working to develop the SB transposon system for human gene therapy, with hemophil...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 04/01/10 - 03/31/12

DESCRIPTION (provided by applicant): Primary immune deficiencies comprise a group of inherited genetic disorders caused by interruption of normal lymphoid development. These diseases are considered prime candidates for gene therapy by introduction of the missing gene into hematopoietic stem cells that can then differentiate into lymphoid cells,...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-07-81
Budget: 08/15/08 - 07/31/10

DESCRIPTION (provided by applicant): The overall goal of Discovery Genomics, Inc. is to develop the Sleeping Beauty transposon system for human gene therapy. To achieve this to treat hemophilia, we must be able to direct uptake and long-term expression of therapeutic genes in targeted tissues such as the liver. Only one method of plasmid deliver...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 04/01/08 - 03/31/10

DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a rare, autosomal recessive inherited disease caused by the absence of any of eight different proteins that regulate DNA repair. Affected individuals suffer from bone marrow failure early in life. FA can be effectively treated by allogeneic hematopoietic stem cell transplant. However, m...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-06-21
Budget: 07/01/07 - 06/30/10

DESCRIPTION (provided by applicant): Discovery Genomics, Inc. is focused on development of the Sleeping Beauty (SB) transposon system as a non-viral means of integrating new gene sequences in cells and tissues for therapeutic purposes. Here we propose to develop a method for improved targeting of the SB system to specific cell types following sy...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-06-21
Budget: 06/01/07 - 08/31/09

DESCRIPTION (provided by applicant): Glioblastoma Multiforme (GBM) is a lethal brain tumor that typically causes death within two years after initial diagnosis. GBM accounts for 25% of all primary brain tumors in adults. Despite improvements in precise surgical de-bulking, radiation, and drug therapy, the prognosis for GBM patients has not signi...

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