Cengent Therapeutics, Inc.

San Diego, CA 92127

SBIR Award Summary

Total Number of Awards 12
Total Value of Awards $2.45MM
First Award Date 04/01/99
Most Recent Award Date 04/15/04

Key Personnel

Last Name Name Awards Contact
Shenderovich Mark D Shenderovich 1
Wang Jing Wang 1
Rideout Darryl C Rideout 3
Zhu Hengyi Zhu 3
Niemeyer Christina C Niemeyer 2
Mutomba Martha C Mutomba 2

12 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/15/04 - 04/14/05

DESCRIPTION (provided by applicant): Der, essential bacterial GTPase, unique and highly conserved in the prokaryotes, is an attractive target for a novel class of antibiotics. We propose a structure-based approach to develop small molecule inhibitors that block GTP binding site of Der GTPase domain GDI. The structure-based inhibitor design will...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/03 - 07/31/04

DESCRIPTION (provided by applicant): Bacillus anthracis, the cause of Anthrax, poses a considerable danger because of its potential use in bioterrorism. Respiratory anthrax infections are almost invariably fatal despite antibiotic treatment. Existing vaccines provide no protection against certain strains of B. anthracis. A small drug-like molecu...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/03 - 02/29/04
PI: Jing Wang

DESCRIPTION (provided by applicant): Epidermal growth factor (EGF) receptor is a cell surface receptor involved in a number of cancers. Inhibition of its intracellular kinase domain with small molecules has recently been proven to have clinical efficacy. We propose a novel approach to block activation of the EGF receptor using small molecules...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/02 - 07/31/03

DESCRIPTION (provided by applicant): Bacillus anthracis, the cause of Anthrax, poses a considerable danger because of its potential use in bioterrorism. Respiratory anthrax infections are almost invariably fatal despite antibiotic treatment. Existing vaccines provide no protection against certain strains of B. anthracis. A small drug-like molecu...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/02 - 05/31/04

DESCRIPTION: IL-5 is an essential cytokine for the maturation of eosinophil precursors to eosinophils, and it is those eosinophils that have been found to correlate with the severity of the late asthmatic reaction. Thus, design of IL-5 receptor antagonists that block pulmonary eosinophil disorders and present a new a...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/02 - 02/28/04

DESCRIPTION (Adapted from the application): HER2 is a transmembrane receptor tyrosine kinase overexpressed and amplified in nearly 30 percent of cancers. It is associated with poor prognosis, chemoresistance, and aggressive and metastatic tumor growth. Herceptin, a humanized monoclonal antibody to HER2, is current...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/01 - 05/31/02

DESCRIPTION: IL-5 is an essential cytokine for the maturation of eosinophil precursors to eosinophils, and it is those eosinophils that have been found to correlate with the severity of the late asthmatic reaction. Thus, design of IL-5 receptor antagonists that block pulmonary eosinophil disorders and present a new a...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/01 - 02/28/02

DESCRIPTION (Adapted from the application): HER2 is a transmembrane receptor tyrosine kinase overexpressed and amplified in nearly 30 percent of cancers. It is associated with poor prognosis, chemoresistance, and aggressive and metastatic tumor growth. Herceptin, a humanized monoclonal antibody to HER2, is current...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/00 - 06/30/01

Overexpression of Bcl-2 has been found in a number of nonhematopoietic cancers, including prostate cancer, breast cancer, and colon cancer. Bcl-2 overexpression in these cells has been found to render cells markedly more resistant to the cytotoxic effects of almost all available anti-cancer drugs. Thus, design of Bcl-2 antagonists will promote s...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/99 - 08/31/00

DESCRIPTION: (Adapted from the applicant's abstract) IL-5 is a T cell derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils. Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma ...

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