DNA Polymerase Technology, Inc.

St. Louis, MO 63104

SBIR Award Summary

Total Number of Awards 15
Total Value of Awards $3.85MM
First Award Date 04/01/00
Most Recent Award Date 07/01/15

Key Personnel

Last Name Name Awards Contact
Rowlyk Katherine R Rowlyk 2 Message
Kermekchiev Milko B Kermekchiev 9 Message
Barnes Wayne Morris Barnes 2 Message
Zhang Zhian Zhang 3

15 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 07/01/15 - 06/30/16

DESCRIPTION (provided by applicant): The objective of this application is to introduce a novel, simplified, low cost technology to address the broad need of detecting RNA pathogens directly in crude samples, such as blood. Traditional RT-PCR requires purifying the RNA which increases the cost, time, and risk of cross-contamination. We intend to ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 07/01/14 - 06/30/15

DESCRIPTION (provided by applicant): The objective of this application is to introduce a novel, simplified, low cost technology to address the broad need of detecting RNA pathogens directly in crude samples, such as blood. Traditional RT-PCR requires purifying the RNA which increases the cost, time, and risk of cross-contamination. We intend to ...

Phase 2 SBIR

Agency: National Science Foundation
Topic: 2011
Budget: 01/01/11 - 12/31/11

This Small Business Innovation Research (SBIR) Phase II project proposes the development of novel enzymes (DNA polymerases) and other improvements for rapid detection of food-borne pathogens by DNA detection and amplification (PCR). PCR is a very fast and accurate method of pathogen detection, typically giving results in about a day, instead of ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 08/01/10 - 01/31/12

DESCRIPTION (provided by applicant): We propose to develop a highly simplified and improved method of detecting RNA for use in clinical tests and for scientific research by enabling the RT-PCR amplification of nucleic acids directly in whole blood, serum, plasma, and cell lysates. We propose a dual approach. We will work with two of our blood in...

Phase 1 SBIR

Agency: National Science Foundation
Topic: 2009
Budget: 01/01/09 - 12/31/09

This Small Business Innovation Research (SBIR) Phase I project proposes the improvement of real-time PCR, a DNA-based rapid-detection method, for detection of food-borne pathogens such as Salmonella. Current methods are inadequate to accurately detect pathogens in foods such as chocolate, soft-cheese, and milk, which are inhibitory to PCR. The...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/07/07 - 03/06/09

DESCRIPTION (provided by applicant): The sensitivity of gene detection in blood specimens in important clinical and forensic PCR applications is limited due to inhibitory blood substances which reduce amplification efficiency and may lead to false negative results. Different pre-PCR treatments that are being used to overcome this inhibitory effe...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/07/06 - 03/06/07

DESCRIPTION (provided by applicant): The sensitivity of gene detection in blood specimens in important clinical and forensic PCR applications is limited due to inhibitory blood substances which reduce amplification efficiency and may lead to false negative results. Different pre-PCR treatments that are being used to overcome this inhibitory effe...

Phase 2 SBIR

Agency: Department of Agriculture
Topic: 2006
Budget: 01/01/06 - 12/31/06

Gene detection in soil using the Polymerase Chain Reaction (PCR) is nearly impossible due to the inhibitory affects of the components of soil, including humic acid. Currently, the DNA must be extracted from the soil in order to perform PCR. The DNA extraction/purification step is expensive and time consuming. We intend to develop commercially av...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/08/05 - 03/06/06

DESCRIPTION (provided by applicant): The success and sensitivity of DNA detection is limited in important clinical, forensic, and environmental applications due to the presence of complex biological samples, such as blood, which reduce amplification efficiency. Different pre-PCR treatments that are being used to overcome this inhibitory effect i...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 2005
Budget: 01/01/05 - 12/31/05

Detection of microbes directly in soil is difficult. The purpose of this study is to identify enzymes which will enable gene detection direclty in crude soil samples.

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