Acera Biosciences, Inc.

Hastings, MN 55033

SBIR Award Summary

Total Number of Awards 6
Total Value of Awards $657K
First Award Date 09/01/99
Most Recent Award Date 02/10/03

Key Personnel

Last Name Name Awards Contact
Mao Yingqing Mao 1
Xue Yongquan Xue 3
Reynolds Kevin A Reynolds 1
Sheldon Paul J Sheldon 1

6 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/10/03 - 01/31/05

DESCRIPTION (provided by applicant): Marine natural products are diverse in chemical structure and have great biological activities, especially anticancer activities. However, developing these compounds into clinical drugs has been hindered by their limited supply. Acera Biosciences, Inc. has developed a strategy to produce these compounds in...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/15/02 - 07/14/03

DESCRIPTION (provided by applicant): The structural and biosynthetic similaritybetween FR900482 and mitomycin (MC) group of antitumor antibiotics makes it promising to rationally create novel mitomycin/FR900482 hybrids through combinatorial biosynthesis. After successful identification of both MC and FR900482 biosynthetic gene clusters, Acera Bi...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/01 - 08/31/02

DESCRIPTION (provided by applicant): Glycosyltransferases involved in linking polyketide macrolactones with deoxysugars are key enzymes for combinatorial biosynthesis of novel macrolide anti-infective agents. In this proposal, a new gene shuffling technology, RACHITT, is applied to the desosarninyl transferase (Des VI...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/00 - 01/31/02

Ketolide antibiotics have recently attracted significant interest because they have activity against a number ofmacrolide-resistant microorganisms, in particular staphylococci and enterococci. The overall objective of this research program is to use combinatorial biosynthesis and biochemical pathway engineering to produce novel functionalized ke...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/00 - 04/30/01

DESCRIPTION (Adapted from the application): The desosaminyl transferase, DesVII, from methymycin/pikromycin biosynthetic pathway of Streptomyces venezuelae, is proposed for use in in vitro glycosylation of polyketide libraries generated by combinatorial biosynthesis. Preliminary genetic studies have de...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/99 - 02/29/00

The overall commercial aim of this project is to create new ketolide antiinfective agents using combinatorial biosynthesis technologies. The specific aims are: l) to develop a versatile plasmid-host expression system in Streptomyces venezuelae through which pikromycin analogues can be generated rapidly and systematically; and 2) generate novel k...