Divergence, Inc.

1005 N WARSON RD
Saint Louis, MO 63132

SBIR Award Summary

Total Number of Awards 26
Total Value of Awards $5.14MM
First Award Date 09/01/01
Most Recent Award Date 07/15/10

26 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-115
Budget: 07/15/10 - 02/21/11

DESCRIPTION (provided by applicant): The goal of this project is to develop a rapid and accurate immunodiagnostic test for detection of soil- transmitted helminths (STHs) that can be used without laboratory infrastructure. Human STH infections from whipworm (Trichuris), roundworm (Ascaris), and hookworms (Necator and Ancylostom...

Phase 2 SBIR

Agency: Department of Agriculture
Topic: 8.2-2010
Budget: 01/01/10 - 12/31/10

An estimated one-third of worldwide crop production is lost to pathogens including fungi. Despite advances in chemical control, the onset of resistance limits the utility of current fungicides. In addition, most pesticide research projects are terminated because of unattractive attributes of the lead chemical series, such as toxicity, manufactur...

Phase 1 SBIR

Agency: National Science Foundation
Topic: CT.-2010
Budget: 01/01/10 - 12/31/10

This SBIR Phase I project will develop novel nematicides using proprietary chemical design and screening methods. The project will first design, prioritize, and synthesize a set of entirely novel molecules. The project will then evaluate compounds for activity in multiple biological assays with parasitic nematodes and plants. Promising scaffo...

Phase 2 SBIR

Agency: National Science Foundation
Topic: 2009
Budget: 01/01/09 - 12/31/09

This Small Business Innovation Research (SBIR) Phase II project will use RNA interference (RNAi) to limit damage to corn from the plant parasite lesion nematode by silencing genes in the parasite. Phase I demonstrated in culture that expression of specific double-stranded RNAs (dsRNAs) from lesion genes limited nematode reproduction and increase...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 09/01/08 - 08/31/10

DESCRIPTION (provided by applicant): Parasitic filarial nematodes causing lymphatic filariasis and river blindness (onchocerciasis), infect over 140 million people with up to one billion at risk in at least 80 countries and territories. Lymphatic filariasis (caused by Wuchereria and Brugia species) creates an enormous health and economic burden ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 06/01/08 - 05/30/09

DESCRIPTION (provided by applicant): Invasive fungal infections are an increasingly common and serious cause of illness and death in the U.S. and worldwide. Infection by Candida albicans has increased tenfold to become more frequent than diseases caused by E. coli and Pseudomonas, and it has become one of the most common fatal infections in the ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 03/01/08 - 02/28/09

DESCRIPTION (provided by applicant): Parasitic infect over 140 million people, with up to one billion at risk in 80 countries. Lymphatic filariasis creates an enormous health and economic burden within affected areas and is the second leading cause of long-term disability. In 2000, international groups including the World Health Organization (WH...

Phase 2 SBIR

Agency: Department of Agriculture
Topic: 2008
Budget: 01/01/08 - 12/31/08

The goal of this research is to generate crops, such as tomato, corn and carrot, with broad spectrum, season long resistance to root knot nematode. Plant parasitic nematodes, of which root knot is the most significant, annually cause damage in excess of $8 billion in the U.S. and $80 billion worldwide. Transgenic crops have a significant economi...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 2008
Budget: 01/01/08 - 12/31/08

Non Technical Summary: Current estimates indicate that one-third of worldwide agricultural output is lost to pests and diseases such as pathogenic fungi. Despite advancements in chemical control, the rapid onset of resistance to pesticides often limits their utility. In addition, the vast majority of pesticide research projects are terminated be...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 2008
Budget: 01/01/08 - 12/31/08

Non Technical Summary: The goal of this research is to generate transgenic crops with broad-spectrum, season-long resistance to root knot nematode (RKN, Meloidogyne sp.). Plant parasitic nematodes, of which RKN is the most significant, annually cause damage of $8 billion in the U.S. and $78 billion worldwide. This project proposes to use RNA int...

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