Discoverx Corporation

Fremont, CA 94538

SBIR Award Summary

Total Number of Awards 17
Total Value of Awards $3.98MM
First Award Date 09/28/00
Most Recent Award Date 09/27/07

Key Personnel

Last Name Name Awards Contact
Eglen Richard M Eglen 5
Khanna Pyare L Khanna 10
Olson Keith Olson 2

17 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 09/27/07 - 05/31/08

DESCRIPTION (provided by applicant): Kinases mediate the biological actions of neurotransmitters, hormones and growth factors and because of their role in disease, they have been a major target for the development of novel therapeutics to treat cancer, autoimmune disorders, diabetes, and brain diseases. In this grant, we propose to develop a nov...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 08/01/07 - 04/30/08

DESCRIPTION (provided by applicant): Cell surface receptors mediate the biological actions of growth factors. Most growth factor receptors are activated by ligand induced homo or heterodimerization. Because of their role in regulating cellular functions and the diseases caused by their disregulation, much interest exists in the pharmaceutical in...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-27
Budget: 09/20/06 - 09/19/07

DESCRIPTION (provided by applicant): GPCRs are a family of cell surface proteins involved in mediating many of the biological actions of neurotransmitters in the brain. They play a critical role in CNS physiology and are a major target for drug discovery in the pharmaceutical industry. The majority of GPCRs in the brain are orphans, with no know...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/06 - 02/29/08

DESCRIPTION (provided by applicant): Transcription factors (TF) are key regulators of gene expression. Most TFs reside in the cytosol and when activated translocate to the nucleus to stimulate gene activity. A therapeutically important TF is NFkB which stimulates genes involved in cell cycling, proliferation and inflammatory responses and is an...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/05 - 08/31/06

DESCRIPTION (provided by applicant): Transcription factors (TF) are key regulators of gene expression. Most TFs reside in the cytosol and when activated translocate to the nucleus to stimulate gene activity. A therapeutically important TF is NFkB which stimulates genes involved in cell cycling, proliferation and inflammatory responses and is an...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/03/04 - 06/30/05

DESCRIPTION (provided by applicant): Ionic conductance channels (ICC) mediate the transport of ions across the cell membrane and are critical for maintaining membrane excitability. ICC consists of multiple subunits that combine to create the unique conductance properties of the channel. Subunits also confer ligand binding domains for neurotransm...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/04 - 02/28/05

DESCRIPTION (provided by applicant): Growth factors are a family of polypeptides necessary for the development of all cells in the body. They regulate cell proliferation and abnormal growth factor activity is involved in cancer and other cell proliferative disorders. Because of their medical uses in treating disease, growth factors have become ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/04 - 03/31/05

DESCRIPTION (provided by applicant): Protein kinases are a family of enzymes that play a pivotal role in signal transduction and have become an important molecular target for drug development. In our phase I SBIR grant, we developed a universal protein kinase assay which employs our proprietary CEDIA(r) technology and consists of measuring the c...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/03 - 04/30/04

DESCRIPTION (provided by applicant): Proteases are critical enzymes involved in the cleavage of proteins to smaller peptides and are important molecular targets for drug discovery. Few cell-based technologies exist to assay specific cleavage of substrates by proteases in a HTS format, which has hindered drug discovery against proteases. DiscoveR...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/03 - 05/31/04

DESCRIPTION (provided by applicant): G protein coupled receptors (GPCRs) are a family of membrane proteins that mediate the biological actions of neurotransmitters and hormones and are a major target for pharmaceutical drug development. Of the top 200 best selling drugs, over 40 of them target GPCRs and those drugs generate over $20 billion. At ...

Load More