Microbiotix, Inc.

WORCESTER, MA 01605
http://www.microbiotix.com

SBIR Award Summary

Total Number of Awards 125
Total Value of Awards $58.7MM
First Award Date 09/30/01
Most Recent Award Date 09/01/17

Key Personnel

Last Name Name Awards Contact
Butler Michelle M. Butler 20
Moir Donald T Moir 27
Bowlin Terry L Bowlin 13
Opperman Timothy J Opperman 16
Peet Norton P Peet 8
Basu Arnab Basu 10
Barnes Marjorie H Barnes 3
Li Bing Li 2
Nguyen Son Truong Nguyen 2
Lory Stephen Lory 2
Williams John D Williams 7
RONG LIJUN RONG 8
KOMAZIN-MEREDITH GLORIA KOMAZIN-MEREDITH 1
MAIRA-LITRAN TOMAS MAIRA-LITRAN 2
MECSAS JOAN C. MECSAS 2
ARON ZACHARY DAVID ARON 2
SHAHRARA SHIVA SHAHRARA 1

125 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-16-375
Budget: 09/01/17 - 06/30/18

Abstract. Approximately 2.5 million Americans have rheumatoid arthritis (RA), which is one of the most common chronic autoimmune disorders in the older population. There is no cure for RA, and up to 40% of patients do not respond to current therapies. As a result, disease progression leads to joint destruction and severe disability in the elderl...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 08/18/17 - 07/31/18

Summary/Abstract The overall objective of this project is to test and prioritize aminospectinomycin (amSPC) antibacterials for use as broad-spectrum agents against bacterial sexually transmitted diseases (STDs). The amSPCs, like their parent antibiotic, spectinomycin (SPC), act by inhibiting bacterial protein synthesis by binding to a ribosomal...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-14-072
Budget: 08/01/17 - 07/31/18

? DESCRIPTION (provided by applicant): The inability to treat many Gram-negative bacterial infections effectively with existing antibiotics is a major medical crisis. Pseudomonas aeruginosa is a prime example: 30% of clinical isolates from critically ill patients are resistant to three or more drugs. The overall goal of this project is to add...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-15-270
Budget: 08/01/17 - 07/31/18

Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are non-segmented negative- strand viruses (NNSV) and are the leading causes of acute respiratory tract infections in infants worldwide. In addition, hRSV is a significant cause of disease in elderly populations and can often be fatal for patients with compromised immune s...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 06/01/17 - 05/31/18

Abstract Multi-drug resistance (MDR) in Gram-negative pathogens, including Pseudomonas aeruginosa, poses a significant threat for effective treatment of infections caused by these organisms. A major component in the development of the MDR phenotype in P. aeruginosa is overexpression of the Resistance Nodulation Development (RND)-family efflux pu...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 06/01/17 - 05/31/18

? DESCRIPTION (provided by applicant): Ebola virus (EBOV) is a member of the filovirus family that causes severe viral hemorrhagic fever (VHF). Although infrequent, epidemics of EBOV can cause high mortality rates of up to 90%; the subsequent medical and social upheaval can be widespread and severe, as seen in the recent outbreak in Western A...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 02/01/17 - 01/31/18

? DESCRIPTION (provided by applicant): Multi-drug resistance (MDR) in Gram-negative pathogens, including the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms. A major component in the development of the MDR phenotype in Gram-negative bacteria is ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 01/27/17 - 12/31/17

ABSTRACT Recombinant adeno-associated virus (rAAV) is a promising gene delivery vector for therapeutic and vaccine applications, but its low transduction efficacy currently limits its utility. The primary reasons for low transduction efficacy are as follows: (i) inefficient trafficking of the rAAV genome to the nucleus, (ii) inefficient host cel...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-14-072
Budget: 08/19/16 - 07/31/17

? DESCRIPTION (provided by applicant): The inability to treat many Gram-negative bacterial infections effectively with existing antibiotics is a major medical crisis. Pseudomonas aeruginosa is a prime example: 30% of clinical isolates from critically ill patients are resistant to three ormore drugs. The overall goal of this project is to addre...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-15-270
Budget: 08/01/16 - 07/31/17

Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are non-segmented negative-strand viruses (NNSV) and are the leading causes of acute respiratory tract infections in infants worldwide. Inaddition, hRSV is a significant cause of disease in elderly populations and can often be fatal for patients withcompromised immune syst...

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