Molecular Therapeutics, Inc.

Ann Arbor, MI 48108

SBIR Award Summary

Total Number of Awards 11
Total Value of Awards $3.6MM
First Award Date 04/15/01
Most Recent Award Date 09/01/06

Key Personnel

Last Name Name Awards Contact
Reddy G R Reddy 7
Nikam Savita Nikam 1
Sunkara Prasad Sunkara 3

11 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-09
Budget: 09/01/06 - 12/31/06
PI: G R Reddy

DESCRIPTION (provided by applicant): Project Summary/Abstract: Although surgery and radiation are typically used in the treatment of malignant gliomas, the prognosis and 5-year survival rate for these patents is very poor. Gliomas are typically radioresistant and represent 1 of the most difficult tumors to treat by noninvasive methods. Gemcitabi...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/05 - 10/31/05

DESCRIPTION (provided by applicant): Mucositis, also called stomatitis, is a debilitating inflammation and ulceration of the lining of the mouth, throat or gastrointestinal tract most commonly associated with radiotherapy or chemotherapy for cancer. In many cases, mucositis can be extremely painful, preventing the patient from eating normally an...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PAR-01-102
Budget: 09/30/04 - 09/29/06
PI: G R Reddy

DESCRIPTION (provided by applicant): The goal of this Phase II project is to continue development of a novel molecular imaging reporter construct that can report induction of apoptosis in intact cells and animals. Under normal biological conditions a tight balance between proliferation and cell death (apoptosis) is essential. An imbalance in the...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAS-02-149
Budget: 08/01/04 - 07/31/06

DESCRIPTION (provided by investigator): There are two key steps involved in the ability of anthrax toxin to target and kill mammalian cells. The first step involves binding to the mammalian cell surface through the recently cloned Anthrax Toxin Receptor (ATR). The second step involves proteolytic cleavage of the anthrax toxin-PA (protective anti...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PAR-01-102
Budget: 09/30/03 - 09/29/04
PI: G R Reddy

DESCRIPTION (provided by applicant): The goal of this Phase II project is to continue development of a novel molecular imaging reporter construct that can report induction of apoptosis in intact cells and animals. Under normal biological conditions a tight balance between proliferation and cell death (apoptosis) is essential. An imbalance in the...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAS-02-149
Budget: 08/01/03 - 07/31/04

DESCRIPTION (provided by investigator): There are two key steps involved in the ability of anthrax toxin to target and kill mammalian cells. The first step involves binding to the mammalian cell surface through the recently cloned Anthrax Toxin Receptor (ATR). The second step involves proteolytic cleavage of the anthrax toxin-PA (protective anti...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-01-102
Budget: 05/15/03 - 04/30/04
PI: G R Reddy

DESCRIPTION (provided by applicant): The long term goal of the proposed project is to develop a novel nanoparticle for both molecular imaging and treatment of brain tumors. This Phase I project will contribute to this goal by the synthesis and characterization of a polyacrylamide based-nanoparticle which can be manufactured to contain a contr...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PAR-01-102
Budget: 09/30/02 - 09/29/03
PI: G R Reddy

DESCRIPTION (provided by applicant): The goal of this Phase II project is to continue development of a novel molecular imaging reporter construct that can report induction of apoptosis in intact cells and animals. Under normal biological conditions a tight balance between proliferation and cell death (apoptosis) is essential. An imbalance in the...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-00-18
Budget: 08/12/02 - 07/31/03
PI: G R Reddy

DESCRIPTION (provided by applicant):The long term goal of the present proposal is to develop a nanoparticle that can be targeted to tissues with specific molecular signatures. Inclusion of a contrast agent (Iron Oxide for MRI) within the nanoparticle would therefore facilitate non-invasive imaging of specific biochemical properties within tissue...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-01-102
Budget: 05/17/02 - 05/16/03

Recent advances in molecular biology and the imaging sciences have created an historic opportunity to non-invasively probe cellular and molecular events associated with the ever-expanding myriad of new pathologic-related genes and proteins in vivo in both animas and humans. There exists a significant opportunity to bridge this great divide betw...

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