Transmembrane Biosciences

2585 Nina Street
Pasadena, CA 91107
16 Employees

SBIR Award Summary

Total Number of Awards 14
Total Value of Awards $3.5MM
First Award Date 01/01/02
Most Recent Award Date 04/25/13

Key Personnel

Last Name Name Awards Contact
Nguyen Dr. Hiep-Hoa T. Nguyen 14 Message

14 Awards Won

Phase 2 SBIR

Agency: Defense Health Program
Topic: OSD11-H05
Budget: 04/25/13 - 07/31/15

The objective of this proposal is to develop an alternative to the tuberculin test and interferon-release assays for the diagnosis of active and latent tuberculosis. Toward this end, a rapid lateral flow test based on the detection of blood antibodies specific to Mycobacteria tuberculosis antigens will be devised for the serodiagnosis of activ...

Phase 1 SBIR

Agency: Defense Health Program
Topic: OSD11-H05
Budget: 12/15/11 - 07/15/12

The objective of this proposal is to develop an alternative to the tuberculin test and interferron-gamma release assays for the diagnosis of active and latent tuberculosis. Toward this end, a rapid test based on the detection of blood antibodies specific to Mycobacteria tuberculosis antigens will be devised for the serodiagnosis of active and la...

Phase 2 SBIR

Agency: Army
Topic: A08-178
Budget: 01/16/10 - 02/15/12

The objective of this proposal is to develop a highly sensitive point-of-care rapid test assay for the diagnosis of Q-fever. Selected highly immunogenic and unique surface-membrane proteins from Coxiella burnetii, the causative agent for Q-fever will be the basis for the rapid test assay. We will utilize the antigens and antibodies prepared duri...

Phase 2 SBIR

Agency: National Science Foundation
Topic: BE7-2010
Budget: 01/01/10 - 12/31/10

This Small Business Innovation Research (SBIR) Phase II project concentrates on creating a novel, economical and powerful production technology for eukaryotic membrane proteins, a group of proteins that remain intractable yet are of tremendous medical and scientific importance. A majority of membrane proteins are very difficult to obtain in any ...

Phase 1 SBIR

Agency: Army
Topic: A08-181
Budget: 01/27/09 - 08/26/09

The objective of this proposal is to develop point-of-care rapid test assay for the diagnosis of Crimean-Congo hemorrhagic fever. Selected surface membrane-bound glycoprotein antigens and the N-nucleoprotein from a number of Crimean-Congo hemorrhagic fever virus (CCHFV) strains will be prepared using powerful recombinant protein mass-production...

Phase 1 SBIR

Agency: Army
Topic: A08-178
Budget: 01/20/09 - 01/15/10

The objective of this proposal is to develop point-of-care rapid test assay for the diagnosis of Q-fever. Selected surface membrane protein antigens from Coxiella burnetii, the causative agent of Q-fever will be prepared using TransMembrane Biosciences powerful membrane protein mass production technologies. This methodology allows correctly f...

Phase 1 SBIR

Agency: Department of Agriculture
Topic: 2008
Budget: 01/01/08 - 12/31/08

Recombinant subunit vaccines are gaining traction in recent development efforts and will constitute the majority of vaccines in the future. One of the major problems in designing recombinant protein subunit vaccines is that the antigens are often membrane proteins found on the surface of the pathogens. Expression technologies commercially availa...

Phase 1 SBIR

Agency: National Science Foundation
Topic: 2008
Budget: 01/01/08 - 12/31/08

This Small Business Innovation Phase I research concentrates on creating overexpression technology for eukaryotic membrane proteins, a group of membrane proteins that remain intractable yet are of significant medical importance. A majority of membrane proteins are very difficult to obtain in significant quantity, even at milligram scale, since ...

Phase 1 SBIR

Agency: Department of Energy
Topic: 2007
Budget: 01/01/07 - 12/31/07

A majority of membrane proteins are very difficult to obtain in significant quantities, even at milligram scale, because their natural biosynthesis levels often are very low, and currently available protein expression systems are not effective for membrane proteins. With the completion of several genome sequencing projects, many large-scale eff...

Phase 1 SBIR

Agency: Defense Advanced Research Projects Agency
Topic: SB052-025
Budget: 10/21/05 - 06/01/06

The objective of the proposal is to create prototype(s) for a microorganism-based fluorescent biosensor for the detection of nerve gas agents. The biosensor is derived from the enzyme organophosphorous hydrolase and the bacterial periplasmic binding proteins. The main sensor units are double fusion constructs with N-terminus and C-terminus lin...

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