Layton Bioscience, Inc.

Sunnyvale, CA 94086

SBIR Award Summary

Total Number of Awards 12
Total Value of Awards $2.22MM
First Award Date 05/01/97
Most Recent Award Date 09/01/02

Key Personnel

Last Name Name Awards Contact
Mcgrogan Michael P Mcgrogan 8
Engelman Robert W Engelman 1
Aboody Karen S Aboody 2
Willing Alison E Willing 1

12 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/02 - 08/31/03

DESCRIPTION (provided by applicant): hNT-Neurons are pure human neuronal cells that exhibit neuronal phenotypes and efficiently engraft following transplantation into rodent spinal cord. Phase I studies successfully developed hNT-Neurons with properties suitable for spinal cord transplantation, ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/02 - 07/31/04

Neural stem cells (NSCs) show a remarkable ability to migrate throughout the CNS, intermingle with host cells, and express foreign transgenes following transplantation. Intriguingly, this inherent migratory property of NSCs emulates the migratory pattern of some brain tumors, such as gliomas, characterized by invasive single cell migration. Pote...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/01 - 08/31/02

DESCRIPTION (provided by applicant): hNT-Neurons are pure human neuronal cells that exhibit neuronal phenotypes and efficiently engraft following transplantation into rodent spinal cord. Phase I studies successfully developed hNT-Neurons with properties suitable for spinal cord transplantation, ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/13/01 - 07/31/02

Neural stem cells (NSCs) show a remarkable ability to migrate throughout the CNS, intermingle with host cells, and express foreign transgenes following transplantation. Intriguingly, this inherent migratory property of NSCs emulates the migratory pattern of some brain tumors, such as gliomas, characterized by invasive single cell migration. Pote...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/01 - 06/30/02

DESCRIPTION (provided by applicant): Development of Ntera2/D1 neurons as an alternative to embryonic neurons for transplantation therapy to ameliorate neurological deficits, currently in a Phase I trial for stroke symptoms, led to our discovery of a 40-60 kDA anionic protein with an isoelectric point of 4.8 express...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/04/00 - 07/31/02

DESCRIPTION: (adapted from abstract): This is a first time Phase I application to investigate the stability and viability of hNT neurons exposed to lithium to increase DA-type phenotype. hNT neurons ar...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/26/00 - 12/25/00

Transplanted neural stem cells (NSCs) show a remarkable ability to migrate throughout the CNS, intermingle with host cells, and express foreign transgenes in vivo. Intriguingly, this inherent migratory property of NSCs emulates the migratory pattern of some brain tumors such as gliomas, characterized by invasive single cell migration. We postula...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/07/00 - 09/06/00

Transplantation of neural tissue into the functionally compromised CNS shows great promise as a treatment for stroke and other neurological disorders. The widespread clinical use of this technique is constrained by the current limited supply of neural cells suitable for transplantation. To overcome this problem, Layton Bioscience, Inc. has devel...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/99 - 08/31/01

DESCRIPTION: hNT are post-mitotic, terminally differentiated human neuronal cells that can be transplanted into the central nervous system as a treatment for neurological disorders. The dopaminergic properties of hNT-neurons include evidence of dopamine synthesis and metabolism in vitro, make them a supe...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/10/99 - 01/09/00

DESCRIPTION: (Verbatim from the Applicant's Abstract) Neuronal replacement therapy is a promising approach for the treatment of spinal cord injury. The unique properties of hNT-Neurons make tem a potential source of cells for this purpose. hNT-Neurons are pure, post-mitotic, differentiated human neuronal cells t...

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