Topogen, Inc.

BUENA VISTA, CO 81211

SBIR Award Summary

Total Number of Awards 8
Total Value of Awards $1.46MM
First Award Date 08/01/97
Most Recent Award Date 09/01/16

Key Personnel

Last Name Name Awards Contact
Spitzner Joseph Spitzner 1
Pan Xing Q Pan 2
Chung In Kwon Chung 1
Lee Gun E Lee 1
Lee Bongyong Lee 1
MULLER MARK T MULLER 2

8 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 09/01/16 - 08/31/17

? DESCRIPTION (provided by applicant): Epigenetic modifications of DNA and histones are stable encryption systems essential for life. For example, the importance of DNA methylation is underscored by the consequences of its mis-regulation, which include defects in tissue homeostasis, chronic disease and accelerated aging; thus epigenetics broa...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 09/05/15 - 08/31/16

DESCRIPTION (provided by applicant): Epigenetic modifications of DNA and histones are stable encryption systems essential for life. For example, the importance of DNA methylation is underscored by the consequences of its mis-regulation, which include defects in tissue homeostasis, chronic disease and accelerated aging;thus epigenetics broadly im...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 07/01/09 - 06/30/11

DESCRIPTION (provided by applicant): Drugs that target topoisomerase action are effective anticancer agents and a number are FDA approved. There is a critical need for cell-based, tractable screening assays that facilitate detection of the next generation of anticancer drugs that specifically target topoisomerase enzymes. In this SBIR, the corp...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 07/14/08 - 06/30/10
PI: Gun E Lee

DESCRIPTION (provided by applicant): Drugs that target topoisomerase action are effective anticancer agents and a number are FDA approved. Anti-topoisomerase therapy is predicated on subverting the endogenous topoisomerase into a genotoxic, DNA damaging agent. A significant problem with such drugs is collateral damage in normal cells. Since all ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/04 - 02/28/05

DESCRIPTION (provided by applicant): DNA methylation is an essential process in growth and development in animals. The importance of DNA methylation in man is underscored by the consequences of its mis-regulation, which include and serious genetics defects and cancer. The process is complicated by the fact that methylation is carried out by a nu...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-00-090
Budget: 08/01/02 - 07/31/03

The objective of this project is to design and evaluate novel folate conjugates targeted to the prostate-specific membrane antigen (PSMA) for prostate cancer imaging. In the Phase I project period, the Specific Aims are: 1. To synthesize novel folate conjugates and determine their affinity for prostate cancer cells in vitro; a series of four fol...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-00-090
Budget: 08/14/01 - 08/13/02

The objective of this project is to design and evaluate novel folate conjugates targeted to the prostate-specific membrane antigen (PSMA) for prostate cancer imaging. In the Phase I project period, the Specific Aims are: 1. To synthesize novel folate conjugates and determine their affinity for prostate cancer cells in vitro; a series of four fol...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/97 - 01/31/98

A growing need for graphically displaying and accessing genetic sequence information has been generated by the large (and increasingly larger) quantity of sequence data available to researchers. Despite this need, there are no generally acceptable standards for encoding and transmitting graphic di...