GTC Biotherapeutics, Inc.

Framingham, MA 01702

SBIR Award Summary

Total Number of Awards 13
Total Value of Awards $3.6MM
First Award Date 08/01/97
Most Recent Award Date 09/01/07

Key Personnel

Last Name Name Awards Contact
Echelard Yann Echelard 2
Ziomek Carol Ziomek 2
Godke Robert A. Godke 1
Dobrinski Ina Dobrinski 3
Schindler Daniel G. Schindler 3
Meade Harry M Meade 2

13 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 09/01/07 - 08/31/09

DESCRIPTION (provided by applicant): The objective of this Phase II SBIR project is to build on the success of a Phase 1 SBIR FLAIR grant to produce and characterize a chimeric form of antibody against human CD137 that is suitable for human clinical testing. CD137 (also called 4-1BB) is a membrane glycoprotein that is inducibly expressed on huma...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 09/29/06 - 08/31/07

DESCRIPTION (provided by applicant): The objective of this Phase II SBIR project is to build on the success of a Phase 1 SBIR FLAIR grant to produce and characterize a chimeric form of antibody against human CD137 that is suitable for human clinical testing. CD137 (also called 4-1BB) is a membrane glycoprotein that is inducibly expressed on huma...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/06 - 02/28/08

DESCRIPTION (provided by applicant): The objective of this proposal is to produce transgenic goats by manipulation of the male germ line through male germ cell transfection and transplantation. The goats will carry the gene for human growth hormone (rhGH) under the control of a mammary gland specific promoter such that the milk of transgenic fem...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-04-61
Budget: 09/26/05 - 12/31/06

DESCRIPTION (provided by applicant): The overall goal of this program is to provide an abundant, cost-effective, biosecure source of human alpha-1 antitrypsin for human therapeutic use by producing recombinant human alpha-1 antitrypsin (rhAAT) in the milk of transgenic goats. Human alpha-1 antitrypsin is currently isolated from donated human pla...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/09/05 - 09/08/06

DESCRIPTION (provided by applicant): The overall goal of this program is to provide an abundant, cost-effective, biosecure source of human albumin for human therapeutic use by producing recombinant human albumin (rhA) in the milk of transgenic cows. Human albumin is isolated from donated human plasma, but shifts in the plasma fractionation indu...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/05 - 02/28/06

DESCRIPTION (provided by applicant): The objective of this proposal is to produce transgenic goats by manipulation of the male germ line through male germ cell transfection and transplantation. The goats will carry the gene for human growth hormone (rhGH) under the control of a mammary gland specific promoter such that the milk of transgenic fem...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/29/04 - 09/30/06

DESCRIPTION (provided by applicant): The objective of this proposal is to produce tetraploid embryos for aggregation with nuclear transfer embryos for the production of transgenic cattle and goats. GTC Biotherapeutics (formerly Genzyme Transgenics Corporation) has developed the expression of recombinant proteins in the milk of transgenic dairy a...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/09/04 - 09/08/05

DESCRIPTION (provided by applicant): The overall goal of this program is to provide an abundant, cost-effective, biosecure source of human albumin for human therapeutic use by producing recombinant human albumin (rhA) in the milk of transgenic cows. Human albumin is isolated from donated human plasma, but shifts in the plasma fractionation indu...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAR-03-074
Budget: 04/15/04 - 03/31/05

DESCRIPTION (provided by applicant): The objective of this proposal is to establish the feasibility of producing anti-human CD137 antibody, an immune modulator that may be effective against solid tumors, in the milk of transgenic animals. CD137 (also called 4-1BB) is a membrane glycoprotein that can be induced in several types of lymphoid cells....

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/15/03 - 12/14/04

DESCRIPTION (provided by applicant): The objective of this proposal is to produce homozygous cell lines from existing hemizygous transgenic goats and cows, for use in producing homozygous transgenic animals. GTC Biotherapeutics (formerly Genzyme Transgenics Corp) has developed a safe, abundant and cost effective production source for recombinant...

Load More