Phylonix Pharmaceuticals, Inc.

100 INMAN ST, STE 300
Cambridge, MA 02139

SBIR Award Summary

Total Number of Awards 80
Total Value of Awards $18.4MM
First Award Date 09/15/98
Most Recent Award Date 05/01/12

Key Personnel

Last Name Name Awards Contact
Serbedzija George N Serbedzija 7
Willett Catherine E Willett 14 Message
Seng Wen L Seng 21
Parng Chuenlei Parng 10
Haldi Maryann L Haldi 11
Semino Carlos Eduardo Semino 2
Ton Christopher Ton 1
Li Chunqi Li 9
Park Demian Park 4
Bello Musodiq O Bello 1
Bello Musodiq O Bello 0
D'Amico Louis J D'Amico 1
McGrath Patricia McGrath 3 Message

80 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 05/01/12 - 04/30/13

DESCRIPTION (provided by applicant): Although conventional sample handling can be adapted for use with processing zebrafish, development of appropriate analytical tools has not kept pace with the increasing use of this animal model for compound screening. In this research, we propose to develop a device to automate zebrafish processing. Zebrafis...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 05/01/11 - 04/30/12

DESCRIPTION (provided by applicant): Although conventional sample handling can be adapted for use with processing zebrafish, development of appropriate analytical tools has not kept pace with the increasing use of this animal model for compound screening. In this research, we propose to develop a device to automate zebrafish processing. Zebrafis...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 09/01/10 - 08/31/12
PI: Chunqi Li

DESCRIPTION (provided by applicant): Cytochrome P450 (CYP) enzymes catalyze the majority of known drug metabolism and the bulk of these reactions occur in the liver. As a consequence, many clinically relevant drug-drug interactions are associated with inhibition and/or induction of a specific CYP enzyme. Modifications of CYP activities can have ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 05/07/10 - 11/30/11
PI: Chunqi Li

DESCRIPTION (provided by applicant): In this research, we will develop zebrafish as a new xenotransplant animal model to assess brain cancer progression and identify potential drug candidates. Brain cancer accounts for approximately 10 - 30% of adult cancers and many forms of cancer can metastasize to the brain. Although immunodeficient mice an...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 04/01/10 - 04/30/11

DESCRIPTION (provided by applicant): Although conventional sample handling can be adapted for use with processing zebrafish, development of appropriate analytical tools has not kept pace with the increasing use of this animal model for compound screening. In this research, we propose to develop a device to automate zebrafish processing. Zebrafis...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-120
Budget: 09/18/09 - 05/31/10

Project Summary/Abstract Neuronal apoptosis has been shown to be involved in pathogenesis of several neurodegenerative disorders including Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotophic Lateral Sclerosis (ALS) and stroke. Currently, there is no simple method to assess neuronal apoptosis or neuroprotection in vivo in vertebrates. ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-006
Budget: 09/14/09 - 06/30/11

DESCRIPTION (provided by applicant): The zebrafish has become an important new animal model for drug screening, target identification, and validation of various disease models. Although progress has been made in adapting image based high- content screening systems, there are several challenges for automation. To date, the quantitative evaluation...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 09/08/09 - 08/31/10
PI: Chunqi Li

DESCRIPTION (provided by applicant): Cytochrome P450 (CYP) enzymes catalyze the majority of known drug metabolism and the bulk of these reactions occur in the liver. As a consequence, many clinically relevant drug-drug interactions are associated with inhibition and/or induction of a specific CYP enzyme. Modifications of CYP activities can have ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-120
Budget: 09/01/09 - 08/31/11

DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the two leading causes of blindness in adults in the industrialized world. Both conditions involve vascular abnormalities, proliferation and leakage of new blood vessels. Retinopathy of prematurity (ROP) is a major cause of newborn blind...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 07/01/09 - 02/28/11
PI: Chunqi Li

DESCRIPTION (provided by applicant): Reactive oxygen species (ROS) are known to contribute as pathogenic factors to the development of chronic progressive diseases at various stages. ROS are also involved in a variety of different cellular processes ranging from apoptosis and necrosis to cell proliferation and carcinogenesis. ROS are well recogn...

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