Inologic, Inc.

Seattle, WA 98103

SBIR Award Summary

Total Number of Awards 7
Total Value of Awards $1.56MM
First Award Date 09/26/97
Most Recent Award Date 08/01/06

Key Personnel

Last Name Name Awards Contact
Traynor-Kaplan Alexis E Traynor-Kaplan 7

7 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/06 - 07/31/08

DESCRIPTION (provided by applicant): Inositol signaling molecules (ISMs) have been linked to regulation of ion channels. Evidence indicates that an lnsP4, myo-inositol 3,4,5,6-tetrakisphosphate [lns(3,4,5,6)P4] and its analogs regulate CI- channels in multiple epithelia. While inositol polyphosphates are highly charged, making them unlikely to c...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/22/05 - 07/31/06

DESCRIPTION (provided by applicant): Inositol signaling molecules (ISMs) have been linked to regulation of ion channels. Evidence indicates that an lnsP4, myo-inositol 3,4,5,6-tetrakisphosphate [lns(3,4,5,6)P4] and its analogs regulate CI- channels in multiple epithelia. While inositol polyphosphates are highly charged, making them unlikely to c...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/02 - 03/31/03

DESCRIPTION (provided by applicant): Here, we propose to demonstrate the feasibility of ameliorating symptoms of cystic fibrosis (CE) by administration of pro-drugs to affected tissues that deliver analogs of specific intracellular messengers, namely inositol polyphosphates, which regulate ion channels. We will test the hypothesis that a membra...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/25/01 - 01/24/02

(Applicant's Abstract): A major complication of CF is prolonged lung inflammation in response to infections. Agents produced during infections exacerbate the underlying defect in cystic fibrosis, inadequate fluid secretion. The investigators hypothesize that two of these exacerbating agents, EGF and TGFalpha ac...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/00 - 02/28/01

DESCRIPTION: (adapted from applicant's abstract) Cystic fibrosis (CF) is due to defects in apical epithelial chloride channel, the cystic fibrosis transmembrane regulator (CFTR). CF can usually be traced with single point mutation in the CFTR which renders it incapable of transfer to the outer membran...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/99 - 02/29/00

DESCRIPTION: (adapted from applicant's abstract) Cystic fibrosis (CF) is due to defects in apical epithelial chloride channel, the cystic fibrosis transmembrane regulator (CFTR). CF can usually be traced with single point mutation in the CFTR which renders it incapable of transfer to the outer membran...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/26/97 - 08/30/98

DESCRIPTION (Adapted from applicant's abstract): Cystic fibrosis (CF) is due to various defects in an apical epithelial Cl- channel, the cystic fibrosis transmembrane regulator (CFTR). The disease can usually be traced to a single point mutation in CFTR that renders it incapable of transfer t...