Cytokine Network, Inc.

Seattle, WA 98119

SBIR Award Summary

Total Number of Awards 4
Total Value of Awards $0.0
First Award Date 09/30/97
Most Recent Award Date 02/01/99

Key Personnel

Last Name Name Awards Contact
Todaro George J Todaro 1
Rice Glenn Rice 1
Sunkara Prasad Sunkara 1
Naftzger Clarissa C Naftzger 1

4 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/99 - 01/31/00

Interleukin-12 (IL-12) is a cytokine important for cell mediated immunity and has potent anti-tumor activities. Systemic IL-12 therapy has generated substantial clinical interest as a treatment for several forms of refractory cancers. Unfortunately, the toxicities of IL-12 have severely limited its clinical us...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/98 - 09/29/99

DESCRIPTION: (Adapted from the applicant's abstract) A group of recently described guanylhydrazone compounds inhibit macrophage activation through multiplicative inhibition of production of specific pro-inflammatory cytokines (TNF, IL-1beta, IL-6, MIP-1alpha, MIP-1beta) and nitric oxide (NO). The lead compoun...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/98 - 07/31/99

Spermine is a ubiquitous and endogenous polyamine that is overexpressed in numerous human tumors. Spermine potently inhibits macrophage activation at physiologic concentrations, and enhanced synthesis and secretion of spermine by tumor cells may play a critical role in the ability of tumors to ev...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 06/30/98

Recent studies have identified a novel population of blood-borne cells, termed fibrocytes, that have a distinct cell surface phenotype (CD34+/collagen +/CD13+/CD45+), and express each of the known surface components that are required for antigen presentation, including class I and class ll MHC molecu...