Mirus BIO Corporation

Madison, WI 53719

SBIR Award Summary

Total Number of Awards 56
Total Value of Awards $14.4MM
First Award Date 09/26/97
Most Recent Award Date 09/05/08

Key Personnel

Last Name Name Awards Contact
Hagstrom James E Hagstrom 5
Trubetskoy Vladimir S Trubetskoy 3
Herweijer Hans Herweijer 14
Lewis David Lawrence Lewis 6
Wooddell Christine I Wooddell 1
Subbotin Vladimir M Subbotin 1
Wong So C Wong 3
Watt Mary-Anne V Watt 5
Sebestyen Magdolna G Sebestyen 8
Rozema David B Rozema 5
Harding Cary O. Harding 1
Acsadi Gyula Acsadi 1
Danko Istvan Danko 1
Monahan Sean D Monahan 1
Bruse Shannon Eric Bruse 1

56 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 09/05/08 - 08/31/10

DESCRIPTION (provided by applicant): In the healthy human body the rate of red blood cell production is controlled by the hypoxia-regulated expression of erythropoietin (EPO). Patients suffering from various chronic diseases often develop anemia that can be alleviated by EPO replacement therapy. Currently, exogenous EPO is provided as a frequent...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 04/01/08 - 10/31/09

DESCRIPTION (provided by applicant): 6. Project Summary/Abstract MicroRNAs (miRNAs) are a group of small, non-coding RNAs, approximately 19-23 nucleotides in length, that regulate gene expression by binding to sequences within the 3' untranslated regions of specific target mRNAs; a single miRNA might bind to and regulate as many as 200 diverse t...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-97
Budget: 04/01/08 - 03/31/09

DESCRIPTION (provided by applicant): Given its central role in metabolism, the secretion of circulating proteins, and infectious disorders, a large number of genetic or acquired disorders could be corrected by liver-directed delivery of nucleic acids to instill beneficial functions or inhibit deleterious ones. However, a safe and effective deliv...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 02/01/08 - 07/31/09
PI: So C Wong

DESCRIPTION (provided by applicant): Given its central role in metabolism and in the secretion of circulating proteins, a large number of genetic or acquired disorders could be corrected by liver-directed gene therapy. However, a safe and effective delivery method for transferring nucleic acids molecules to hepatocytes remains to be perfected. F...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-80
Budget: 09/28/07 - 08/31/08

DESCRIPTION (provided by applicant): This project aims to identify peptides that can be used to target drugs (small molecules, biologicals, DNA, siRNA) specifically to liver tumor cells. We will use phage display selection techniques to identify such peptides. The incidence of liver cancer, either primary or metastatic, is increasing. Convention...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 05/01/07 - 04/30/09

DESCRIPTION (provided by applicant): We have invented a safe and simple method for naked DNA delivery into limb muscles, the hydrodynamic limb vein injection, which is a clinically viable procedure holding great promise for the treatment of various inherited and acquired diseases. This technology increased the efficiency of naked DNA delive...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-97
Budget: 04/10/07 - 03/31/08

DESCRIPTION (provided by applicant): Given its central role in metabolism, the secretion of circulating proteins, and infectious disorders, a large number of genetic or acquired disorders could be corrected by liver-directed delivery of nucleic acids to instill beneficial functions or inhibit deleterious ones. However, a safe and effective deliv...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 04/10/07 - 03/31/08

DESCRIPTION (provided by applicant): 6. Project Summary/Abstract MicroRNAs (miRNAs) are a group of small, non-coding RNAs, approximately 19-23 nucleotides in length, that regulate gene expression by binding to sequences within the 3' untranslated regions of specific target mRNAs; a single miRNA might bind to and regulate as many as 200 diverse t...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-20
Budget: 03/15/07 - 01/31/08
PI: So C Wong

DESCRIPTION (provided by applicant): Given its central role in metabolism and in the secretion of circulating proteins, a large number of genetic or acquired disorders could be corrected by liver-directed gene therapy. However, a safe and effective delivery method for transferring nucleic acids molecules to hepatocytes remains to be perfected. F...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic: PA-06-07
Budget: 09/20/06 - 08/31/08

DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is the most prevalent lethal motor neuron disease in adults and there is no effective therapy available. The primary defect in ALS is the degeneration of upper and lower motor neurons causing subsequent muscle weakness and atrophy. Neurotrophic factors have potential in the...

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