Applied Genetics Laboratories, Inc.

Melbourne, FL 32904

SBIR Award Summary

Total Number of Awards 12
Total Value of Awards $99.9K
First Award Date 08/16/93
Most Recent Award Date 07/01/01

Key Personnel

Last Name Name Awards Contact
Liechty Melissa C Liechty 3
Davis Lisa M Davis 6
Rotenberg Mitch O Rotenberg 2
Hozier John C Hozier 1

12 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/01 - 06/30/02

APPLICANT?S DESCRIPTION: This proposal describes technical approaches for efficient and high throughput production of region specific genomic and cDNA microarrays with the ultimate goal of deciphering cancer-associated genes involved in various human neoplasias. The techniques will be applied to the human 5q31-qter region for feasibility studies...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/98 - 09/29/00

This proposal describes methods for producing high density sets of reagents for genetic and physical mapping, using our recently developed methods for preparing chromosome region specific probes and screening entire bacterial artificial chromosome (BAC) libraries in one simple experiment. The probes ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/98 - 02/29/00

AGL proposes to develop a new, generally applicable method for the positional cloning of human growth suppressor genes. This approach merges the Selection of Hybrids by Affinity Capture technique (SHAC), developed at AGL, with the Suppression Subtractive Hybridization technique (SSH) and an ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/98 - 09/30/00

This proposal describes a method for preparing cDNA sublibraries specific to certain chromosome regions. The procedure, which we call selection of hybrids by affinity capture (SHAC), can be described in two stages. In the first stage, banded mitotic chromosomes are microdissected and PCR- amplified using a unive...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 09/29/98

This proposal describes methods for producing high density sets of reagents for genetic and physical mapping, using our recently developed methods for preparing chromosome region specific probes and screening entire bacterial artificial chromosome (BAC) libraries in one simple experiment. The probes ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 03/30/99

Several attempts have been made to make cDNA libraries from small amounts of tissues utilizing PCR to amplify the cDNA. These cDNA libraries were inadequate for several reasons. We propose to develop new techniques to prepare high quality cDNA libraries from small numbers of functionally defined ce...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/97 - 05/31/98

This proposal describes a method for preparing cDNA sublibraries specific to certain chromosome regions. The procedure, which we call selection of hybrids by affinity capture (SHAC), can be described in two stages. In the first stage, banded mitotic chromosomes are microdissected and PCR- amplified using a unive...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/96 - 09/29/97

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/95 - 09/29/96

DESCRIPTION (Adapted from applicant's abstract): Chromosome-specific DNAs will be prepared for all mouse and rat chromosomes by combining the technologies of chromosome microdissection and degenerate oligonucleotide primed PCR (DOP-PCR) amplification. Difficulties with flow sorting of chromosomes have prevented complete sets of chromosome-sp...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/95 - 08/15/96

This proposal describes a method for preparing cDNA sublibraries specific to certain chromosome regions. The procedure, which we call selection of hybrids by affinity capture (SHAC), can be described in two stages. In the first stage, banded mitotic chromosomes are microdissected and PCR- amplified using a unive...

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