Onyx Pharmaceuticals

Richmond, CA 94806

Market Performance

NASDAQ: ONXX
52 Week Low $N/A

SBIR Award Summary

Total Number of Awards 5
Total Value of Awards $113K
First Award Date 07/01/96
Most Recent Award Date 04/01/00

Key Personnel

Last Name Name Awards Contact
Polakis Paul G Polakis 3
Laquerre Sylvie Laquerre 1
Abo Arie Abo 1

5 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/00 - 03/31/01
PI: Arie Abo

The accessory protein HIV-Nef plays an important role in the regulation of HIV pathogenesis. Recently we and others have shown that Nef is associated with the host protein kinase known as Nef Associated kinase (NAK). Recruitment of NAK by Nef is an important step for HIV production. NAK inhibitors will introduce a novel class of anti-HIV drugs t...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/99 - 03/31/00

Cancer is a principal cause of death in the United States and new approaches to prevent or treat the disease are clearly needed. Clinical studies using a tumor selective human adenovirus (ONYX-015) have demonstrated that a replication competent virus can be engineered to be safe, specific and in several cases cause tumor necrosis. These results ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/98 - 05/31/99

The APC gene is mutated in almost all colon cancers, which rank second as a cause of cancer related mortality. APC has been placed in a signaling pathway involving its regulation of beta-catenin, a protein now known to activate transcription. Abnormal accumulation of beta-catenin is observed in cancer c...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 09/29/98

The APC gene is mutated in almost all colon cancers, which rank second as a cause of cancer related mortality. APC has been placed in a signaling pathway involving its regulation of beta-catenin, a protein now known to activate transcription. Abnormal accumulation of beta-catenin is observed in cancer c...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/96 - 12/31/96