Somagenics, Inc.

Santa Cruz, CA 95060

SBIR Award Summary

Total Number of Awards 51
Total Value of Awards $18.1MM
First Award Date 09/15/94
Most Recent Award Date 08/01/17

Key Personnel

Last Name Name Awards Contact
Johnston Brian H. Johnston 25
Kazakov Sergei A Kazakov 16
Kaspar Roger L Kaspar 6
Jayasena Sumedha Jayasena 1
BARBERAN-SOLER SERGIO BARBERAN-SOLER 3

51 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 08/01/17 - 07/31/18

ABSTRACT This proposal addresses the problem of sequence bias in next-generation sequencing (NGS) of small RNAs such as microRNAs (miRNAs) as well as fragments of larger RNAs. Because dysregulation of miRNA expression has been implicated in cancer and other diseases, accurate expression profiling of all miRNA sequences is important for understan...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 07/10/17 - 04/30/18

Abstract The goal of this grant application is to develop the first commercially available library preparation kit for profiling small RNAs from single cells using NGS methods. Single cell analyses of mRNA have allowed the identification of crucial differences between cells that were otherwise considered identical. These findings have shown that...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-16-302
Budget: 05/01/17 - 04/30/18

The goal of the proposed research is to develop an improved method, RealSeq-DC, to prepare libraries of cell-free DNA (cfDNA) for next-generation sequencing (NGS). cfDNAs, which are found in blood and in other bodily fluids, represent promising, minimally invasive ?liquid biopsy? samples for human cancer and prenatal diagnosis of fetal genetic d...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-15-269
Budget: 09/28/16 - 07/31/17

ABSTRACT This proposal addresses the problem of sequence bias in next-generation sequencing (NGS) of small RNAs such as microRNAs (miRNAs) as well as fragments of larger RNAs. Because dysregulation of miRNA expression has been implicated in cancer and other diseases, accurate expression profiling of all miRNA sequences is important for understan...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-335
Budget: 03/01/16 - 02/28/17

? DESCRIPTION (provided by applicant): Recent discoveries highlight the importance of extracellular miRNAs (ex-miRNAs) as promising noninvasive biomarkers for many diseases. It has also been reported that several ex-miRNAs species might be important for cell-cell signaling. While there is still controversy about their biological importance, i...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-14-071
Budget: 02/01/16 - 10/31/16

? DESCRIPTION (provided by applicant): Quantification of gene expression in formalin-fixed paraffin-embedded (FFPE) tissue samples is important for the discovery and validation of cancer biomarkers, for tumor classification, and to assess progress during cancer treatment. Because RT-qPCR assays are very sensitive and sequence-specific, they a...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/01/15 - 08/31/16

DESCRIPTION (provided by applicant): The growing populations of the elderly and those with type-II diabetes are at high risk for developing chronic wounds that are slow to heal. Effective therapeutics to promote wound healing could significantly improve the lives of these people. Normal wound healing involves a coordinated cascade of events that...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-335
Budget: 03/15/15 - 02/29/16

DESCRIPTION (provided by applicant): Recent discoveries highlight the importance of extracellular miRNAs (ex-miRNAs) as promising noninvasive biomarkers for many diseases. It has also been reported that several ex-miRNAs species might be important for cell-cell signaling. While there is still controversy about their biological importance, it is ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-13-234
Budget: 09/24/14 - 08/31/15

DESCRIPTION (provided by applicant): The growing populations of the elderly and those with type-II diabetes are at high risk for developing chronic wounds that are slow to heal. Effective therapeutics to promote wound healing could significantly improve the lives of these people. Normal wound healing involves a coordinated cascade of events that...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-088
Budget: 09/01/14 - 08/31/15

DESCRIPTION (provided by applicant): Hepatitis D virus (HDV) infection is the most severe type of viral hepatitis, often causing accelerated liver damage that leads to end-stage liver disease. About 10-15 million individuals are infected by HDV worldwide. The absence of an effective treatment for acute forms of the disease and the limited effica...

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