Chemgen Corporation

16016 Industrial Drive
Gaithersburg, MD 20877
30 Employees

SBIR Award Summary

Total Number of Awards 7
Total Value of Awards $350K
First Award Date 06/16/92
Most Recent Award Date 08/01/96

Key Personnel

Last Name Name Awards Contact
Anderson David M. Anderson PhD 2
Mccandliss Russell J Mccandliss 1
Liu Lin Liu 1
Anderson David M Anderson 3

7 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/96 - 07/31/98

DESCRIPTION: The objective of this Phase II proposal is to complete the genetic development for a low cost, fermentation based, production method for thymidine. Thymidine, currently produced by chemical synthesis, is an important raw material for several anti-viral pharmaceuticals and other biomedical applic...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/95 - 07/31/96

DESCRIPTION: The objective of this Phase II proposal is to complete the genetic development for a low cost, fermentation based, production method for thymidine. Thymidine, currently produced by chemical synthesis, is an important raw material for several anti-viral pharmaceuticals and other biomedical applications. Previous work at ChemGen t...

Phase 2 SBIR

Agency: Army
Topic: A91-066
Budget: 09/02/94 - 09/02/96

The goal of this project is to develop highly efficient means to produce OPA anhydrase enzymes and to purify large quantities for test and evaluation studies. For OPA anhydrases of greatest interest, ChemGen proposes to use recombinant DNA technology in E. Coli for large scale production of the bacterial agent-degrading enzymes. This will invo...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/93 - 02/28/94
PI: Lin Liu

Thymidine is a precursor for the manufacture of two anti-AIDS drugs, AZT and d4T. Currently, thymidine is manufactured primarily through a chemical synthesis process. AZT manufacturing cost is very sensitive to thymidine price since the AZT production process is based on a relatively low yield, multiple-step synthesis from thymidine. Reduction o...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/93 - 02/28/94

Thymidine is used as the raw material for the manufacture of 3'- azidothymidine (AZT), and other thymidine analogs, that are currently used in the treatment of HIV-infected patients. Part of the high cost of AZT is due to the high cost of thymidine. The goal of this project is to engineer a bacterial strain to enable it to make and excrete hig...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/93 - 02/28/94

An analysis of E. coli thymidine producing strains developed with patented ChemGen technology strongly suggests that intracellular production of UDP (or UMP) is now rate limiting for thymidine production. Previous work by ChemGen created a non-feed back inhibited pathway for the efficient synthesis of thymidine from UDP in five steps through th...

Phase 1 SBIR

Agency: Army
Topic: A91-066
Budget: 06/16/92 - 02/11/93