Gentest Corporation

Woburn, MA 01801

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $0.0
First Award Date 08/15/94
Most Recent Award Date 09/30/98

Key Personnel

Last Name Name Awards Contact
Crespi Charles L Crespi 7
Miller Vaughn P Miller 3

10 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/98 - 09/29/00

Cytochromes P450 are the principal enzymes for the metabolism of many drugs, protoxins and environmental pollutants. We propose to further develop and optimize a method for high level production of functional, catalytically active human cytochromes P450 using baculovirus-expression in insect cells. This p...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/98 - 01/31/00

We propose to evaluate the feasibility of expressing human cytochrome P450 (CYP) cDNAs in Caco-2 human intestinal epithelial cells, a model system for the study of drug/xenobiotic uptake and transport. Expression studies will be conducted using CYP2A6 as a convenient and appropriate model enzyme and then e...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/98 - 11/30/98

We propose to develop in vitro systems for studying the disposition of xenobiotics. More specifically, we will evaluate the feasibility of developing improved systems for the study of excretory transport into the bile. Two independent systems will be developed in parallel: (1) new methods for the eff...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 09/30/99

Rabbit FM01 and FM02 and human FM03 cDNAs will be expressed in AHH-1TK+/- human lymphoblastoid cells, AS52 Chinese hamster cells and C3H 10T1/2 mouse cells. FMO expression will be monitored by regio- and stereoselective/enzyme assays and immunoblotting. The level and stability of FMO expression will ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 09/29/98

Cytochromes P450 are the principal enzymes for the metabolism of many drugs, protoxins and environmental pollutants. We propose to further develop and optimize a method for high level production of functional, catalytically active human cytochromes P450 using baculovirus-expression in insect cells. This p...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/97 - 01/31/98

We propose to evaluate the feasibility of expressing human cytochrome P450 (CYP) cDNAs in Caco-2 human intestinal epithelial cells, a model system for the study of drug/xenobiotic uptake and transport. Expression studies will be conducted using CYP2A6 as a convenient and appropriate model enzyme and then e...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/96 - 09/29/97

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/95 - 03/29/96

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 12/15/94 - 06/14/95

We propose to evaluate the feasibility of expressing human cytochrome P450 (CYP) cDNAs in Caco-2 human intestinal epithelial cells, a model system for the study of drug/xenobiotic uptake and transport. Expression studies will be conducted using CYP2A6 as a convenient and appropriate model enzyme and then extended to CYP3A4, the major cytochr...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/94 - 12/01/95

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