Jacobus Pharmaceutical Company, Inc.

Princeton, NJ 08540

SBIR Award Summary

Total Number of Awards 4
Total Value of Awards $1.72MM
First Award Date 09/15/91
Most Recent Award Date 09/01/03

Key Personnel

Last Name Name Awards Contact
Lewis Neil J Lewis 1
Jacobus David P Jacobus 2
Sibley Carol Hopkins Sibley 1

4 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/03 - 08/31/06

DESCRIPTION (Provided by applicant): Plasmodium falciparum is the parasitic protozoan responsible for fatal malaria in humans. It causes about 300 million clinical case of malaria and 2-3 million deaths annually. There is no vaccine against malaria, so selection of drug resistant malaria parasites has been a major factor in increased malaria mor...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/02 - 08/31/03

DESCRIPTION (Provided by applicant): Plasmodium falciparum is the parasitic protozoan responsible for fatal malaria in humans. It causes about 300 million clinical case of malaria and 2-3 million deaths annually. There is no vaccine against malaria, so selection of drug resistant malaria parasites has been a major factor in increased malaria mor...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/99 - 06/30/00

In the malaria parasite, Plasmodium falciparum, resistance to drugs that inhibit dihydrofolate reductase (DHFR) results from point mutations in the DHFR gene. We have engineered yeast whose growth depends upon the DHFR enzyme from drug-sensitive P. falciparum, and shown that these yeast are killed by antimalarial DHFR inhibitors at concentration...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/91 - 09/15/92

The proposed research is designed to develop an improved synthetic method for the production of a new, more bioefficient derivative of pyridoxal isonicotinoyl hydrazone (PIH), an orally active iron chelator for the treatment of iron overload. In Phase I human trials, PIH (given orally in capsules containing the solid free base) produced an amou...