Pharmavene, Inc.

Rockville, MD 20850

SBIR Award Summary

Total Number of Awards 3
Total Value of Awards $0.0
First Award Date 04/05/91
Most Recent Award Date 06/01/93

Key Personnel

Last Name Name Awards Contact
Lynch Thomas J Lynch 1
Couch Richard A Couch 1
Belendiuk George W Belendiuk 1

3 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/93 - 05/31/95

Each year approximately 100,000 people are admitted to hospitals for acute cocaine overdose, yet current treatments are merely palliative. We propose to develop butyrylcholinesterase from human plasma as a safe and effective treatment of cocaine overdose. In contrast to pharmacotherapies, which may have a benefit in treating one medical complic...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/93 - 08/31/93

We have developed a method for producing large quantities of highly purified human plasma butyrycholinesterase and will evaluate this enzyme's potential therapeutic value for inactivating both succinylcholine and mivacurium. The muscle relaxant, succinylcholine, is used by anesthesiologists to ease patient intubation and reduce muscle tone in a...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/05/91 - 08/09/91

Human plasma butyrylcholinesterase (EC 3.1.1.8), also referred to as pseudocholinesterase, is an enzyme with no known biological function. However, it is clinically significant in that it is inhibited by a number of anti-acetylcholinesterase toxins and drugs and is responsible for hydrolyzing and inactivating others. Butyrylcholinesterase is al...