HRI Research, Inc.

Concord, CA 94520

SBIR Award Summary

Total Number of Awards 7
Total Value of Awards $0.0
First Award Date 04/01/91
Most Recent Award Date 08/01/93

Key Personnel

Last Name Name Awards Contact
Lin Lily Lin 7

7 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/93 - 01/31/94
PI: Lily Lin

The long-term goal is to develop photochemical decontamination (PCD) methods for the inactivation of infectious pathogens in blood products. We have previously developed a prototype PCD system for platelet concentrates which utilizes treatment with long wavelength ultraviolet radiation and 8- methoxypsoralen with preservation of in vitro platel...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/93 - 01/31/94
PI: Lily Lin

The long term objective is to develop methodologies and products to facilitate the commercialization of the polymerase chain reaction (PCR) in clinical diagnostics. It is crucial that sample preparation procedures prior to PCR amplification be simplified, and contamination of previously amplified nucleic acid sequences be minimized. In Phase I...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/93 - 01/31/94
PI: Lily Lin

The goal is to develop practical psoralen-based photochemical decontamination (PCD) methods for inactivation of infectious pathogens in blood products. A prototype method using ultraviolet light (UVA) and 8-methoxypsoralen (8-MOP) was developed for platelet concentrates (PC). Although psoralens are highly specific for nucleic acid inactivation,...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/92 - 07/31/93
PI: Lily Lin

The long-term goal is to develop photochemical decontamination (PCD) methods for the inactivation of infectious pathogens in blood products. We have previously developed a prototype PCD system for platelet concentrates which utilizes treatment with long wavelength ultraviolet radiation and 8- methoxypsoralen with preservation of in vitro platel...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/91 - 01/31/92
PI: Lily Lin

DESCRIPTION (Investigator's Abstract): In this phase I proposal the investigators seek to develop a method to inactivate pathogenic human viruses in platelet concentrates expanding on their preliminary work using photochemical decontamination (PCD) with psoralen and UV-A light. Preliminary data have been published showing that the combination o...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/15/91 - 01/14/92
PI: Lily Lin

DESCRIPTION (Investigator's Abstract): The investigator asserts that the principal inhibitor of TAQ polymerase in blood samples is heme. The goal of the revised proposal is to develop chemical, photochemical, enzymatic, or affinity binding methods for the inactivation of heme with a long term objective of allowing PCR to become a routine clini...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/91 - 09/30/91
PI: Lily Lin

Transfusion-associated transmissible diseases such as hepatitis and AIDS remain a significant problem despite extensive donor screening and improved testing of blood units. The demand for blood products for support of immunosuppressed patients undergoing chemotherapy and organ transplantation increases the risk of transfusion associated viral d...