Scios, Inc.

Sunnyvale, CA 94085

SBIR Award Summary

Total Number of Awards 11
Total Value of Awards $375K
First Award Date 01/15/92
Most Recent Award Date 05/26/00

Key Personnel

Last Name Name Awards Contact
Cordell Barbara L Cordell 1
Abraham Judith A Abraham 3
Mischak Ronald P Mischak 1
Stanton Lawrence W Stanton 1
White Robert Tyler White 3
Protter Andrew A Protter 1
Schreiner George F Schreiner 1

11 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/26/00 - 04/30/01

DESCRIPTION (Verbatim from the applicant's abstract): Vascular endothelial growth factor (VEGF) is a highly endothelial cell-specific mitogen capable of stimulating new blood vessel growth (angiogenesis) and collateral- dependent blood flow in vivo. Because of these properties, VEGF has been proposed as a potential pharmacological therapy for th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/99 - 04/30/00

DESCRIPTION (Verbatim from the applicant's abstract): Vascular endothelial growth factor (VEGF) is a highly endothelial cell-specific mitogen capable of stimulating new blood vessel growth (angiogenesis) and collateral- dependent blood flow in vivo. Because of these properties, VEGF has been proposed as a potential pharmacological therapy for th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/98 - 08/31/99

The use of cardiopulmonary bypass (CPB) in cardiothoracic surgery is associated with significant postoperative bleeding and pulmonary injury due to massive activation of plasma protease systems during extracorporeal circulation. Contact activation of the kallikrein- kinin system, intrinsic...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/97 - 02/28/98

DESCRIPTION: (adapted from applicant's abstract) Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen capable of potently stimulating new blood vessel growth (angiogenesis). VEGF-165 and VEGF-121 are two different isoforms of the factor generated from the human VEGF gene by alte...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/97 - 08/31/98

The use of cardiopulmonary bypass (CPB) in cardiothoracic surgery is associated with significant postoperative bleeding and pulmonary injury due to massive activation of plasma protease systems during extracorporeal circulation. Contact activation of the kallikrein- kinin system, intrinsic...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/18/97 - 02/17/98

Brain natriuretic peptide (BNP) is a 32 amino acid, cardiac derived peptide hormone with potent vasodilator, natriuretic, and diuretic actions. Recent clinical studies suggest that BNP is a cardioprotective hormone secreted in response to the chronic hemodynamic and hormona...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/96 - 11/30/96

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/95 - 02/29/96

Neutrophil recruitment to sites of inflammation is necessary for repair of damaged tissue, but in some instances the process may lead to further damage of the involved tissue. The action of Mac-1, an adhesion molecule expressed on the surface of neutrophils, is required for neutrophil recruitment during the ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/95 - 03/31/96

During cardiopulmonary bypass, plasma factor XII is converted to active XIIa by contact with the surfaces of the bypass circuit, initiating a process which results in massive activation of the plasma proteases of the contact system. Products of contact activation include bradykinin from the kallikrein-kinin system...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/95 - 07/31/96

Brain Natriuretic Peptide (BNP) is a cardiac-derived peptide hormone with potent cardiovascular and renal actions. Elevated plasma levels of BNP and its precursor pro-BNP correlate with ventricular hypertrophy and severity of cardiac dysfunction. Commercial radioimmunoassays for BNP are expensive, complex and ...

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