Creative Biomolecules, Inc.

Hopkinton, MA 01748

SBIR Award Summary

Total Number of Awards 15
Total Value of Awards $0.0
First Award Date 05/01/85
Most Recent Award Date 08/01/98

Key Personnel

Last Name Name Awards Contact
Huston James S. Huston 5
Tucker Ronald F Tucker 1
Charette Marc F Charette 4
Tai Mei-Sheng Tai 1
Mccartney John E Mccartney 1
Rutherford R B Rutherford 1
Bosukonda Dattatreyamurty Bosukonda 1
Kaplan Paul L Kaplan 1

15 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/98 - 01/31/99

DESCRIPTION: Osteogenic Protein-1 (OP-1), a member of the BMP subfamily of the TGF-beta superfamily of proteins, has trophic activity primarily on dendrites for a variety of neuronal cell types in culture. Both the protein and its receptor are expressed in the substantia nigra. Using a 6-hyroxy dopamine induc...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 09/29/99

DESCRIPTION: Insults to the dental pulp tissues, in the form of trauma, caries, tooth preparation, or bacterial leakage around restorative materials can result in several sequelae, including the formation of "protective" reparative dentin, chronic inflammatory cell infiltrates within the pulp tissue...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 12/20/96 - 12/31/97

Abstract of Research Plan: This project will determine the high resolution three dimensional structure (3DS) of OP-1 to atomic resolution and use this structure to design small molecules or peptidomimetic agents for treating osteoporosis and other metabolic bone disease. The synergistic relationship between th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/94 - 09/24/95

The goal of this proposed study is the development and refinement of a therapeutic composition that will reliably affect the regeneration of the soft and hard tissue in the periodontium that are lost or damaged due to periodontal disease. During the Phase I portion of this project we have identified a novel composition, platelet-derived growth ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/25/93 - 09/24/94

The goal of this proposed study is the development and refinement of a therapeutic composition that will reliably affect the regeneration of the soft and hard tissue in the periodontium that are lost or damaged due to periodontal disease. During the Phase I portion of this project we have identified a novel composition, platelet-derived growth ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/10/93 - 11/09/93

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/91 - 11/30/92

DESCRIPTION: (Adapted from the Applicant's Abstract) Antibody variable (v) regions each comprise 3 complementary determining regions (CDRs) that form the antigen binding site and 4 framework regions (FRs) that form the scaffold supporting the binding site. These segments are interspersed sequentially in each V region to form FR1-CDR-1 FR2-CDR-...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/91 - 11/30/92

Given the major importance of cardiovascular drugs to public health in this country, it is remarkable that there are still no clinically effective agents that act directly on the fibrin during the clotting process. Such drugs would hold the possibility of avoiding many of the side effects of heparin or thrombolytic therapy. This SBIR grant pro...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/91 - 08/14/91

The goal of this study is the regeneration of soft and hard tissue lost due to periodontal disease. This goal will be tested in Phase I by: (1) formulation of biosynthetic human growth factors in a variety of delivery vehicles; (2) determination of bioavailability in vitro of growth factors in the vehicles; and (3) evaluation of the combination...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/90 - 03/15/91

This project will develop the basis for structure analysis of PDGF-AA in Phase I, leading to its 3D structure determination in PHase II. The ultimate goal of this grant is to use the 3D structure of PDGF to develop drugs that inhibit the actions of PDGF-AA in atherosclerosis. This approach will take advantage of the most contemporary technique...

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