Advanced Tissue Sciences, Inc.

La Jolla, CA 92037

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $940K
First Award Date 06/11/89
Most Recent Award Date 09/01/02

Key Personnel

Last Name Name Awards Contact
Naughton Gail K Naughton 3
Bartel Ronnda L Bartel 1
Riley Susan L Riley 1
Ratcliffe Anthony Ratcliffe 5

10 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/02 - 11/04/02

DESCRIPTION (Provided by Applicant): The long-term objective of this proposal is to generate a cartilage product with mechanical properties comparable to those of adult articular cartilage for the repair of focal articular defects. Based on previous experimental findings, our hypothesis is that mechanical loading...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/01 - 08/31/02

DESCRIPTION (Provided by Applicant): The long-term objective of this proposal is to generate a cartilage product with mechanical properties comparable to those of adult articular cartilage for the repair of focal articular defects. Based on previous experimental findings, our hypothesis is that mechanical loading...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/01 - 04/30/02

DESCRIPTION (Verbatim from Applicant): The long-term objective of this project is to develop tissue-engineered cartilage for human therapy using a novel degradable poly(ethylene glycol) hydrogel. We hypothesize that a semi-interpenetrating polymer network composed of poly(ethylene glycol) dimetha...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/00 - 02/28/02

There is substantial need for a supply of human cartilage for head and neck reconstructive surgery. Septal cartilage provides a viable donor site for chondrocytes that can be expanded using tissue.engineering technologies developed by Advanced Tissue Sciences, Inc. for the treatment of burns and skin ulcers. The overall objective of this applica...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/28/99 - 07/31/00

Tissue engineering has immense potential in the area of cartilage repair, and experimental studies have shown that cartilage constructs can repair small focal defects. Future applications of this technology, to repair large defects, in joints with significant curvature, will require significant development of this technology to overcome two tec...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/99 - 01/31/00

DESCRIPTION (Adapted from the applicant's abstract): The long-term objective of the project is the development of tissue engineered cartilage grown in vitro from isolated cadaveric donor chondrocytes grown on bioresorbable scaffolds for the treatment of human articular cartilage defects. This proposal focuses on modulating improving the biochemi...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/92 - 03/31/93

Advanced Tissue Sciences has developed a suspended nylon screen culture (NSC) system for the growth of bone marrow (BM), liver (L), and skin. The research will develop in vitro models for hematotoxicity and hepatotoxicity. Parenchymal cell growth is achieved on an NSC with stromal support cells from the organ under study. The BM NSC has a mul...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/91 - 02/29/92

DESCRIPTION: (Adapted from the applicant's abstract) A novel physiologic skin mode has been developed utilizing human neonatal dermal fibroblasts cultured on a biodegradable, polyglycolic or polyglactic acid, mesh. The proliferating cells stretch across the mesh opening and secrete native growth factors, collagens and other extracellular matri...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/27/89 - 03/26/90

A physiological three-dimensional long-term culture system has been developed for the growth of bone marrow. This system involves the establishment of stromal cells on a suspended nylon filtration screen, the growth of stromal cells to sub-confluence, and the inoculation of stroma with fresh or cryopreserved bone marrow cells. Stromal elements d...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/11/89 - 12/31/89

A three-dimensional system for the growth of human tissues in vitro has been developed in our laboratory. In this physiological method stromal cells are established on a support matrix and act to provide a foundation for the continued growth and differentiation of cells. Histologically complete bone marrow and skin have been maintained in long...

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