Anatrace, Inc.

Cleveland, OH 44128

SBIR Award Summary

Total Number of Awards 33
Total Value of Awards $1.32MM
First Award Date 04/17/87
Most Recent Award Date 08/01/08

Key Personnel

Last Name Name Awards Contact
Keyes Melvin H Keyes 17
Gray Don N Gray 10
Albert David E Albert 1
Watson Barry Watson 3
Travis Benjamin Ross Travis 2

33 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-75
Budget: 08/01/08 - 07/31/09

DESCRIPTION (provided by applicant): The importance of brain-derived G protein-coupled receptors (GPCRs) in mental function and health can hardly be overstated. However, our knowledge of the molecular biophysical basis for how GPCRs bind to their cognate agonists and antagonists to elicit function is limited by the lack of high resolution 3-D ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-75
Budget: 09/07/07 - 07/31/08

DESCRIPTION (provided by applicant): The importance of brain-derived G protein-coupled receptors (GPCRs) in mental function and health can hardly be overstated. However, our knowledge of the molecular biophysical basis for how GPCRs bind to their cognate agonists and antagonists to elicit function is limited by the lack of high resolution 3-D ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/03 - 03/14/04

DESCRIPTION (provided by applicant): Glycosphingolipids and cholesterol form associations with important signaling proteins, within biological membranes forming what are called "rafts". These rafts are characterized by their insolubility even in the presence of many detergents used in membrane chemistry to isolate proteins from the lipid compone...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/02 - 07/31/04

DESCRIPTION: (provided by applicant) Ainphipols are low molecular weight (<20 kDa) linear polymers having a distribution of polar and hydrophobic side chains which confers amphipaticity to the polymer. Amphipols represent a unique way of solubilizing integral membrane proteins. Amphipols wrap themselves around the hydroph...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/01 - 07/31/02

DESCRIPTION: (provided by applicant) Ainphipols are low molecular weight (<20 kDa) linear polymers having a distribution of polar and hydrophobic side chains which confers amphipaticity to the polymer. Amphipols represent a unique way of solubilizing integral membrane proteins. Amphipols wrap themselves around the hydroph...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/99 - 02/29/00

The aim of this Phase I proposal is to synthesize amphipathic polymer amphipols. These materials will be evaluated as a detergent to solubilize membrane proteins in aqueous solutions without deleteriously increasing the effective molecular weight of the protein. In the first amphipuls described in the latter will be resynthesized and evaluated. ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/99 - 08/31/02

The understanding of protein function is greatly enhanced by the availability of three dimensional structural information obtained by X- ray crystallography. Unfortunately the large, well-ordered three- dimensional crystals required for X-ray analyses have been difficult to produce for membrane pr...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/25/98 - 08/31/99

The understanding of protein function is greatly enhanced by the availability of three dimensional structural information obtained by X- ray crystallography. Unfortunately the large, well-ordered three- dimensional crystals required for X-ray analyses have been difficult to produce for membrane pr...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/98 - 06/30/98

Interfacial phenomena, both desirable and detrimental, are central to many processes in animal cell bioreactors; however, these phenomena in bioreactors and bioprocesses are poorly understood. Currently, the use of surfactants are crucial to the large scale (greater than 100 L) cultivation of suspende...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/97 - 06/30/00

The use of extracorporeal, based therapies continues to grow (dialysis, ECMO, pheresis, detoxification, etc.) and a persistent problem with extracorporeal blood contact devices is one of thrombus formation following contact with surface of synthetic materials. In every instance the extracorporeal circ...

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