Molecular Oncology, Inc.

Gaithersburg, MD 20878

SBIR Award Summary

Total Number of Awards 13
Total Value of Awards $0.0
First Award Date 06/01/89
Most Recent Award Date 09/30/92

Key Personnel

Last Name Name Awards Contact
Liang Chi-Ming Liang 1
Bird Robert E Bird 2
Fridman Rafael A. Fridman 1
Turner Nancy A. Turner 2
King Charles Richter King 5
King C. Richter King 2

13 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/92 - 03/31/93

The goal of the proposal is to develop new organic compounds that have specific anti-metastatic activity for use in adjuvant treatment of cancer patients to inhibit or delay the development of metastatic disease. Inhibition of basement membrane degradation, an important event in the metastatic process will be targeted. Evidence exists linking t...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/92 - 03/31/93

The degradation of basement membrane is important for leukocyte migration, tissue remodeling, wound healing, angiogenesis and tumor invasion. Type IV collagen, the major component of basement membrane, is degraded by type IV collagenase (CIVase) which usually exists in a latent form. The latent CIVase can be activated in vivo to an active form w...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/15/92 - 04/30/93

DESCRIPTION: (Adapted from the Applicant's Abstract) Breast cancer affects over 120,000 women each year in the USA. An increasing number of these women present with early stage disease for which surgery alone is curative for most patients. Unfortunately, a significant number of patients do relapse. Adjuvant chemotherapy has been demonstrated...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/11/92 - 10/31/92

Molecules that contain two distinct antigen binding domains, bispecific antibodies, have shown promise as novel anti-cancer therapeutic agents. To date, such bispecific antibodies have been prepared by two methods. The fusion of two hybridoma cell lines, one of which produces an anti-tumor antibody and one which produces an anti-effector antib...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/06/92 - 06/30/92

DESCRIPTION (Adapted from applicant's abstract):Degradation of collagen IV in basement membranes has been implicated in the pathogenesis of metastasis, and in the process of angiogenesis. The 72 kD and the 92 kD type IV collagenases are metalloproteases capable of degrading collagen IV which have been suggested to play a critical role in the ab...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/91 - 06/30/92

(Adapted from the Investigator's Abstract) Abnormalities of the erbB-2 gene occur in 20-30% of human breast, ovary, and gastric cancers. Overexpression or gene amplification has been associated with a proper disease prognosis. In Phase I, MAbs specific to the erbB-2 protein product were developed and their applications to diagnosis and therapy...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/91 - 11/30/91

DESCRIPTION (Adapted from the applicant's abstract): Metastasis from tumors of epithelial origin such as the lung, colon, breast, and prostate constitute the cause of the majority of cancer related deaths. There exist few experimental systems suitable for the testing of anti-metastatic agents on human epithelial tumors. While many cell lines ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/91 - 04/30/92

DESCRIPTION: (Adapted from the Applicant's Abstract) Breast cancer affects over 120,000 women each year in the USA. An increasing number of these women present with early stage disease for which surgery alone is curative for most patients. Unfortunately, a significant number of patients do relapse. Adjuvant chemotherapy has been demonstrated...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/91 - 10/31/91

The degradation of the collagen type IV network in basement membranes is a critical event in many normal and pathological conditions including tissue remodelling, wound healing, tumor cell metastasis, and angiogenesis. The 72 Kd type IV collagenase is a neutral metalloprotease capable of degrading collagen type IV that has been implicated in th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/90 - 06/30/91

(Adapted from the Investigator's Abstract) Abnormalities of the erbB-2 gene occur in 20-30% of human breast, ovary, and gastric cancers. Overexpression or gene amplification has been associated with a proper disease prognosis. In Phase I, MAbs specific to the erbB-2 protein product were developed and their applications to diagnosis and therapy...

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